180 results
To investigate whether sodium and potassium mutations are found in a cohort of patients with small fiber neuropathy, painful diabetic neuropathy (versus diabetes patients with no or only minor symptoms) and in patients with breast, ovarium or…
This study is a pilot study to investigate whether Spinal Cord Stimulation (SCS) combined with best (drug) treatment as usual (TAU) leads to clinically significant pain relief in patients suffering from pain in the lower limbs due to SFN, defined as…
Objectives: 1. To assess the prevalence of pain in elderly with dementia and to study the relationship between the various subtypes of dementia and the presence of specific types of pain(e.g. nociceptive pain, neuropathic pain, and orofacial pain).…
PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…
To study whether hyqvia is as effective, safe and tolerable (or more tolerable) as IVIg.
De lnternational CIDP Outcome Study (ICOS) aims to describe in detail the variation in clinical and electrophysiological subtypes, current practice of treatment, clinical course and outcom in CIDP. The second objective is to define the clinical and…
The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.
Primary clinical investigation objectives[Safety]The primary safety objective of the clinical investigation is to provide data that demonstrates safety of the device, defined as < 8.3% serious adverse device effects, up to 6 weeks following…
Primary: To explore the diagnostic value to distinguish PAF and MSA of a variety of tests: corneal confocal microscopy optical coherence tomography (OCT) to measure the retinal nerve fibre layer thickness and total macular volume, corneal…
The primary objective of this study is to investigate attenuation of pain and sensory thresholds during dorsal root ganglion stimulation using QST. The secondary objectives of this study are to investigate 1) To assess changes in pain intensity (NRS…
The aim of this study is to further explore ultrasonographic abnormalities of peripheral nerves in patients with NF and their relation with symptoms, findings in neurological examination and electrophysiological characteristics.Primary objective:…
To study whether flavoprotein imaging can be used to diagnose painful polyneuropathy, we first need to investigate whether a reproducible and validated flavoprotein signal can be obtained on the second fingertip of healthy subjects.
PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…
Primary Objectives: * To determine if NA patients have altered cerebral activity related to motor planning of their affected arm compared to healthy controls and compared to their non-affected arm.* To determine if specific rehabilitation focused on…
The purpose of the study is to investigate the effect of (repeated) cast immobilization on the bone strength of the lower leg in patients with diabetes mellitus. In this study, bone strength is examined by cortex thickness in millimeters and density…
The purpose of the study is to investigate how quickly and to what extent EMA401 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). EMA401 will be labeled with 14-Carbon (14C) and is…
The main objective of the study is to determine the PK and PD of IVIg during maintenance treatment in patients with CIDP. These data will be used to conduct a NONMEM analysis in relation to the dosage, frequency and batch of IVIg used. The secondary…
The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.
The aim of the research is to study the effectiveness of PRF treatment on radicular neuropathic pain. The effectiveness will be determined by eQST, VAS and RAND-36 values. To evaluate the effectiveness of the PRF treatment, there will be included a…
Primary objective:To assess the safety of repeat applications of QUTENZA administered over a period of 12 months in subjects with PDPN.Secondary objectives:To assess the efficacy of repeat applications of QUTENZA administered over a period of 12…