Search for a trial

Spinal Cord Stimulation in Small Fibre Neuropathy: A pilot study

This study is a pilot study to investigate whether Spinal Cord Stimulation (SCS) combined with best (drug) treatment as usual (TAU) leads to clinically significant pain relief in patients suffering from pain in the lower limbs due to SFN, defined as…

A Phase I, drug-drug interaction study between oral doses of GLPG1205 and an OCT2 probe substrate (metformin) or a BCRP probe substrate (rosuvastatin) in healthy male subjects

PrimaryTo assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of an OCT2 probe substrate, metformin, in healthy male subjects.To assess the effect of GLPG1205 on the single dose pharmacokinetics (PK) of a BCRP probe substrate,…

Subcutaneous immunoglobulins with rHuPH20 in multifocal motor neuropathy

To study whether hyqvia is as effective, safe and tolerable (or more tolerable) as IVIg.

STOP NEUROMA
Surgical Treatment Of symPtomatic NEUROMA:
Open non-randomized clinical investigation to evaluate the safety and effectiveness of the nerve capping device to prevent neuroma formation after traumatic nerve section

Primary clinical investigation objectives[Safety]The primary safety objective of the clinical investigation is to provide data that demonstrates safety of the device, defined as < 8.3% serious adverse device effects, up to 6 weeks following…

Neuralgic amyotrophy: Central reorganization and rehabilitation after peripheral dysfunction

Primary Objectives: * To determine if NA patients have altered cerebral activity related to motor planning of their affected arm compared to healthy controls and compared to their non-affected arm.* To determine if specific rehabilitation focused on…

A single-center, open-label, single oral dose study to investigate the absorption, distribution, metabolism, and excretion (ADME) and pharmacokinetics of EMA401 after a single dose of [14C]EMA401 in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent EMA401 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). EMA401 will be labeled with 14-Carbon (14C) and is…

Rotterdam Observational Study in CIDP of Pharmacokinetics of Intravenous γ-globulin

The main objective of the study is to determine the PK and PD of IVIg during maintenance treatment in patients with CIDP. These data will be used to conduct a NONMEM analysis in relation to the dosage, frequency and batch of IVIg used. The secondary…

A Randomized, Controlled, Long-term Safety Study Evaluating the Effect of Repeated Applications of QUTENZA plus Standard of Care versus Standard of Care alone in Subjects with Painful Diabetic Peripheral Neuropathy

Primary objective:To assess the safety of repeat applications of QUTENZA administered over a period of 12 months in subjects with PDPN.Secondary objectives:To assess the efficacy of repeat applications of QUTENZA administered over a period of 12…

Development of a nociceptive test battery - inflammatory and neuropathic pain tests.

* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.* Investigation of confounding factors including anxiety, personality, and subject sex.* Explore logistics,…

International Second Immunoglobulin Dose in Guillain-Barre Syndrome patients with poor prognosis.

Primary objectiveTo determine whether a second IVIg dose in GBS patients with a poor prognosis improves functional outcome after 4 weeks.Secondary objectives To investigate whether: - a second IVIg dose in GBS patients with a poor prognosis improves…

ARA 290 Intravenous-Subcutaneous crossover study in normal human volunteers - PKARA Study

To measure the PK of ARA290 when given in de SQ form

An open prospective randomized long-term effectiveness study, comparing best medical practice with or without adjunctive spinal cord stimulation in patients with chronic diabetic neuropathic pain

What is the long-term clinical benefit of best medical practice with and without adjunctive SCS Therapy in patients with chronic diabetic neuropathic pain?

A multicenter, Single arm, Open label study of The Repeated Administration Of Qutenza For The Treatment Of Peripheral Neuropathic Pain.

The purpose of the study is to assess the safety and efficacy of repeated treatments of QUTENZA in subjects with peripheral neuropathic pain.

Treatment of deafferentiation pain using EMDR (Eye Movement Desensitization and Reprocessing)
A randomised-controlled trial including patient with nerve damage in the jaw area.

At time of publication

The long-term effect of the babysitterprocedure after proximal nerve injury.

Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.

Development of a nociceptive test battery - acute pain tests

Primary Objective* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.Secondary Objectives* Investigation of confounding factors including fear of pain, mood, age and…

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Intravenous versus Subcutaneous Immunoglobuline therapy in Multifocal motor neuropathy

1. Primary objective:To evaluate whether subcutaneous immunoglobulin infusion is as effective as intravenous immunoglobulin in maintaining muscle strength in patients with multifocal motor neuropathy.2. Secondary objective:a) To evaluate whether…

Does speech therapy improve the subjective function of the inferior alveolar nerve after a permanent paresthesia due to an advancement procedure of the mandible.

Improvement of the discomfort of the paresthesia, as experienced by the patient.

The kinematics and kinetics of walking using a forefoot offloading shoe in patients with diabetes and periferal neuropathy.

The goal of this study is to compare the kinematics and kinetics of walking in a FOS with a standard shoe in diabetic neuropathic patients.