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The effectiveness of a PRF-DRG treatment on radicular neuropathic pain

The aim of the research is to study the effectiveness of PRF treatment on radicular neuropathic pain. The effectiveness will be determined by eQST, VAS and RAND-36 values. To evaluate the effectiveness of the PRF treatment, there will be included a…

A randomized, four-way crossover, comparative bio-availability study of branded (Neurontin®) and three generic 800 mg gabapentin labels in healthy subjects under fasting conditions.

The aim of this study is to investigate the possible consequences of generic-generic substitution of gabapentin, a frequently used anti-epileptic drug.

A study to investigate the pharmacodynamics, safety and tolerability of cutaneous capsaicin in healthy adult subjects.

-To investigate the feasibility, applicability, safety, tolerability, and reproducibility of addition of the capsaicin-heat model and the thermal grill to the existing nociceptive pain test battery in healthy subjects.-To investigate the feasibility…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

A multicentre, randomized controlled trial of neurolysis for mild ulnar neuropathy at the elbow

Primary objective:The primary objective of this study is to compare the short-term and long-term efficacy of neurolysis and a conservative strategy for relieving symptoms in mild cases of UNE. Secondary objectives:- VAS score for paresthesias- VAS…

Decreasing acute peripheral neuropathy in patients treated with Oxaliplatin
(heated oxaliplatin versus oxaliplatin on room temperature)

Objective: Main object Does warming of oxaliplatin, during the two hours infusion period, reduces the acute peripheral neuropathy complaints of patients with a colo-rectal tumor more than 50% in comparison with the standard treatment?Secondary…

Pain and patient-reported outcome associated with surgery for carpal tunnel syndrome or trigger finger under local anesthesia with and without tourniquet

The aim of this study is to compare pain or discomfort during the ingreep between WALANT and tourniquet use.In addition, we aim to determine whether carpal tunnel release or trigger finger release using WALANT has an effect on recovery, patient-…

Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

(Cost)-effectiveness of lower extremity nerve decompression surgery in diabetic subjects: the DeCompression (DECO) trial

Evaluation of the (cost-)effectiveness of surgical decompression of compressed lower extremity nerves (LEND surgery) compared to patients 'treated' with conventional best care.