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A randomized, single-center, double-blind, placebo-controlled, 2-way cross-over, single oral administration trial to evaluate blood-borne biomarker candidates to predict NOP receptor activation using GRT6010 as NOP receptor agonist in healthy human subjects.

Primair: To assess the change in the CD11b expression in leukocytes and in plasma concentrations of nociceptin after oral single dose administration of 12 mg GRT6010 compared to placeboSecundair:To assess the difference in area of the capsaicin-…

A double blind, placebo controlled Phase 2 dose ranging study of the effects of ARA 290 on corneal nerve fiber density and neuropathic symptoms of subjects with sarcoidosis

ARA290 is a new drug against neuropathic pain and was succesfully tested in previous studies on patients with neuropathic pain due to diabetes and sarcoidosis. The current study involves sarcoidosis patients with pain due to neuropathy. The purpose…

The effect of spinal anesthesia on pain perception and
sedation in healthy volunteers

(1) To assess the effect of deafferentation on pain processing in the brain by task-fMRI(2) To assess the effect of deafferentation on reaction time (sedation) by task-fMRI(3) To assess the effect of deafferentation on endogenous pain modulation

Treatment of Complex Regional Pain Syndrome type 1: A randomized placebo controlled double-blind study with ARA 290, The CRPSARA Study

Study AimsPrimary Aim: This is a proof-of-concept study to evaluate the effect of ARA 290 in pain of patients with CRPS1 by means of once daily subcutaneous injection with ARA 290 for 4 weeks. Secondary Aims: * Assess the predictive effect of…

ARA 290 Intravenous-Subcutaneous crossover study in normal human volunteers - PKARA Study

To measure the PK of ARA290 when given in de SQ form

An open prospective randomized long-term effectiveness study, comparing best medical practice with or without adjunctive spinal cord stimulation in patients with chronic diabetic neuropathic pain

What is the long-term clinical benefit of best medical practice with and without adjunctive SCS Therapy in patients with chronic diabetic neuropathic pain?

A multicentre, randomized controlled trial of neurolysis for mild ulnar neuropathy at the elbow

Primary objective:The primary objective of this study is to compare the short-term and long-term efficacy of neurolysis and a conservative strategy for relieving symptoms in mild cases of UNE. Secondary objectives:- VAS score for paresthesias- VAS…

A multicenter, Single arm, Open label study of The Repeated Administration Of Qutenza For The Treatment Of Peripheral Neuropathic Pain.

The purpose of the study is to assess the safety and efficacy of repeated treatments of QUTENZA in subjects with peripheral neuropathic pain.

A PHASE I, SINGLE-CENTRE, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, SINGLE- AND MULTIPLE ASCENDING-DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF GRC 10693 IN HEALTHY MALE SUBJECTS

The study has three objectives. Firstly, we will study the safety and tolerability of the drug after the administration of both single and multiple doses of the drug. Secondly, we will study the speed at which the drug is absorbed in the body, as…

Treatment of deafferentiation pain using EMDR (Eye Movement Desensitization and Reprocessing)
A randomised-controlled trial including patient with nerve damage in the jaw area.

At time of publication

The long-term effect of the babysitterprocedure after proximal nerve injury.

Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.

A Randomized, Double-Blind, Placebo- and Active-Controlled Study of Carisbamate in the Treatment of Neuropathic Pain in Diabetic Peripheral Neuropathy Followed by a Blinded Extension Phase

OBJECTIVESPrimary ObjectiveThe primary objective is to evaluate the efficacy, safety, and tolerability of 800 and 1,200 mg/day of carisbamate compared with placebo in reducing the average daily pain in subjects with diabetic peripheral neuropathy (…

Randomized, double-blind, placebo-controlled study of the tolerability and pharmacokinetics of ascending single (TDU6964) and 14-day repeated (TDR6966) oral doses of SAR501788 and pilot food variability evaluation (FED6965) in healthy young male subjects - Tolerability and pharmacokinetics of 14-day repeated oral doses of SAR501788 in healthy elderly male and female subjects (TDR6967)

to assess the tolerability and safety after single oral ascending doses of SAR501788 in healthy young male subjects (Part 1)to assess the tolerability and safety after repeated oral ascending doses of SAR501788 in healthy young male subjects (Part 3…

A Phase I, Single-Centre, Randomized, Double-Blind, Placebo Controlled, Multiple Dose Study to Evaluate the Effect of tedalinab on ECG parameters, CNS Function and Pain Perception in Healthy Subjects.

Evaluate the effect of tedalinab on ECG parameters, CNS Function and Pain Perception in Healthy Subjects.

Development of a nociceptive test battery - acute pain tests

Primary Objective* Investigate the feasibility, applicability, safety, tolerability, and reproducibility of nociceptive tests in healthy volunteers.Secondary Objectives* Investigation of confounding factors including fear of pain, mood, age and…

Validation study: a newly developed neuropathic pain Heat-Capsaicin-Warmth (HCW) sensitization model.

Primary:Part I:- to determine the effects of gabapentin and remifentanil on the evoked area of hyperalgesia, area of allodynia, pinprick hyperalgesia and background pain using a newly developed HCW sensitization modelPart II: - to determine…

Influence of S(+)-ketamine on Diffuse Noxious Inhibitory Control (DNIC) and offset analgesia (OA) in chronic pain patients (neuropathic pain, complex regional pain syndrome type 1, fibromyalgia) and healthy volunteers

1. Measure DNIC and offset analgesia in CRPS-1 patients, fibromyalgia patients and neuropathic pain patients;2. Compare DNIC and offset analgesia in chronic pain patients with DNIC and offset analgesia in healthy volunteers;3. Assess the effect of…

Injection with corticosteroids in the sulcus of the elbow (with ultrasound) in patients with an ulnar neuropathy and EMG abnormalities

Whether injection of corticosteroids with use of ultrasound in the cubital tunnel is effective in reducing the symptoms compared with patients with an ulnar neuropathy treated with an injection of NaCl 0.9 % (placebo). Both groups will get the usual…

Intravenous versus Subcutaneous Immunoglobuline therapy in Multifocal motor neuropathy

1. Primary objective:To evaluate whether subcutaneous immunoglobulin infusion is as effective as intravenous immunoglobulin in maintaining muscle strength in patients with multifocal motor neuropathy.2. Secondary objective:a) To evaluate whether…

Decreasing acute peripheral neuropathy in patients treated with Oxaliplatin
(heated oxaliplatin versus oxaliplatin on room temperature)

Objective: Main object Does warming of oxaliplatin, during the two hours infusion period, reduces the acute peripheral neuropathy complaints of patients with a colo-rectal tumor more than 50% in comparison with the standard treatment?Secondary…