Search for a trial

Intravenous immunoglobulin therapy for small fiber neuropathy: a randomized, double-blind, placebo-controlled study on efficacy and safety.

Primary objective: To evaluate the efficacy of IVIg treatment (4 courses of treatment, 3 weeks apart) compared to placebo on pain alleviation. Secondary objectives: 1. Pain intensity, pain qualities, and other SFN related complaints, daily and…

Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP (OPTIC trial)

Primary objective of this randomized controlled trial is to assess whether combining IVIg and IVMP leads to more frequent long-term remission in CIDP compared to treatment with IVIg alone. Main secondary objectives are to assess whether IVIg and…

The effect of spinal cord stimulation and dorsal root ganglion stimulation on histamine induced itch: an experimental pilot study

To determine if SCS and/or DRGS is can influence the perception of experimentally induced pruritus.

Posterior Tibial Tendon Transfer in
Foot Drop; Description and Analysis of the Circumtibial Route

To assess the range and strength of dorsiflexion of the ankle and the percentage of AFO-use after executing a variation on the circumtibial route of the posterior tibial tendon transfer, performed in our center on patients with foot drop.

Mindfulness based cognitive therapy in treatment of chronic pelvic pain

Does mindfulness based cognitive therapy in addition to treatment as usual (TAU) improve QoL compared to TAU alone in patients with CPP based on a hypertonic pelvic floor ?

Effectiveness of neurolysis versus neurectomy of the lateral femoral cutaneous nerve (LFCN) in the treatment of meralgia paresthetica.

The goal of the stomp trial will be to investigate the effectiveness of both the neurolysis and neurectomy procedure in patients with persistent symptoms of meralgia paresthetica. In addition, in this trial we want to determine to what extend…

A randomized controlled trial to evaluate the efficacy of the Spinal Modulation Axium neurostimulator therapy as a treatment for persistent inguinal pain following surgical intervention.

The primary objective of this Randomised Controlled Trial (RCT) is to evaluate the efficacy of DRG stimulation with the Axium® SCS system as compared to CMM in terms of pain relief. Efficacy will be assessed by comparing the percentage of subjects…

VX16-150-102 A Phase 2, Randomized, Double-blind, Placebo-controlled, 6-Week, Parallel-design Study of the Efficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy

Primary Objective:To evaluate the efficacy of VX-150 for the treatment of pain caused by small fiber neuropathy.Secondary Objectives:* To evaluate the safety and tolerability of VX-150* To evaluate the pharmacokinetics (PK) of VRT-1207355 and the…

Magneto-encephalography (MEG) to image the brain*s role in the analgesic effects of Spinal Cord Stimulation (SCS), an explorative study

Image with magneto-encephalography (MEG) the supraspinal effects of conventional and burst SCS settings in patients who already have a spinal cord stimulator, to study the analgesic mechanisms of action of SCS and to improve the treatment of chronic…

Graded Exposure in patients with Painful Diabetic Neuropathy

To investigate the effects of the cognitive behavioural intervention GEXP on physical activity and quality of life, hereby targeting specific fears in patients with PDN.Hypothesis: GEXP, as addition to usual care, increases the levels of physical…

Second IVIg Dose in GBS patients with poor prognosis (SID-GBS trial)

To determine whether a second IVIg course in GBS patients with a poor prognosis improves functional outcome after 4 weeks.

Spinal cord stimulation for treating diabetic neuropathic pain; a validation study

To validate the results from two RCTs that SCS is indeed capable of treating otherwise refractory diabetic neuropathic pain, and to evaluate the effects of burst stimulation settings in this patient group.

A phase I, randomized, placebo-controlled, double blind, first time in human, escalating single-dose study to evaluate the safety, tolerability pharmacokinetics and pharmacodynamics of Neu-P12 in healthy male volunteers

Primary objectiveTo assess safety and tolerability of Neu-P12 in four different single doses of the drug. Secondary objectiveTo compare the pharmacokinetics, pharmacodynamics, safety, and tolerability of different single doses of Neu-P12.

International, multi-center, randomized, double-blind, placebo-controlled phase III study assessing in parallel groups the efficacy and safety of 2 doses of PXT3003 in patients with Charcot-Marie-Tooth Disease type 1A treated 15 months

Primary objective:To assess the efficacy of PXT3003 compared to Placebo on the disability measured by the ONLS score in CMT1A patients treated for 15 months.Secondary objectives:- To assess the efficacy of PXT3003 compared to Placebo on clinical and…