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Efficacy of vitamin D supplementation in preventing peripheral neuropathy in multiple myeloma patients.

The primary objective of this study is to determine the efficacy of vitamin D supplementation on the severity of PN in patients with multiple myeloma.

Shifting pain modulation towards anti-nociceptivity: Mechanism-specific pharmacological prevention of post sternotomy pain

In this research project we explore anti-nociception as a state of pain modulation. Our main objectives in utilizing the plasticity of the central pain pathways are to: (i) Shift individuals from a pro-nociceptive pain modulation profile to an anti-…

Double blind, randomized, 2-way cross-over, placebo controlled study to evaluate the therapeutic and preventive effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model in healthy male subjects

PrimaryTo assess the preventative effect of GLPG1205 on nociceptive and inflammation/sensitization induced pain in the UVB sunburn model using HPTol upon multiple dosing of GLPG1205 versus placebo.SecondaryTo further assess the preventative effect…

Frozen gloves for prevention of chemotherapy-induced peripheral neuropathy

The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.

Value of surgical decompression of the nerves of the lower extremities in patients with painful diabetic polyneuropathy: Lower Extremity Nerve entrapment Study (LENS)

To evaluate the effect of surgical decompression of the nerves in the lower extremities in patients with painful diabetic neuropathy.

The effects of random vibrations on the vibratory perception threshold of the foot and standing balance in people with diabetic neuropathy

To investigate the effects of vibrating insoles on vibration perception threshold (VPT) and balance of people with diabetic neuropathy.

Improving the cost-effectiveness of therapeutic shoes for diabetic patients with a previous foot ulcer using an in-shoe pressure device

The primary objective of this investigator initiated project is to determine whether the use of the WalkinSense in the production of new fully customized therapeutic footwear for diabetic patients with a history of foot ulceration results in lower…

Frozen Gloves in the prevention of polyneuropathy

The goal of this study is to examine the effect of cooling on neuropathy in the hands of patients who are treated with Paclitaxel, Docetaxel en Oxaliplatin. Patients who will be included in the study are those who start with chemotherapy. The…

Peripersonal space and chronic pain (PSCP)

First, we investigate the attention-bias for pain signals that chronic pain patients (CPP) are suggested to have. Second, we investigate whether the chronicity of pain is related to faster learning and slower *unlearning* of new associations between…

Acute peripheral neuropathy in patients treated with oxaliplatin;
Is it possible to decrease the complaints?

Main object Is there a reduction of the acute peripheral neuropathy complaints of patients with advanced or metastatic colorectal cancer due to the infusion of heated oxaliplatin?Does the quality of life of these patients improve?Secondary objectThe…

Improving mobility in diabetic patients through resistance training

The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and…

A randomized double-blind study of N-Acetylcysteine vs. placebo to Prevent Neurotoxicity induced by Platinum containing chemotherapy in patients treated for (Non)Small Cell Lung Cancer and Malignant Mesothelioma.

The primary objective is to establish the neuroprotective efficacy of NAC against cisplatin-induced neurotoxicity. Mainly the sensory neuronal guidance will be assessed before and after treatment with cisplatin in a group of patients receiving NAC…

A SINGLE-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER PILOT STUDY WITH TRAMADOL TO VALIDATE TWO EXPERIMENTAL HUMAN PAIN MODELS AT THE KENDLE CLINICAL PHARMACOLOGY UNIT

To evaluate and implement the cutaneous electrical stimulation pain model at the Kendle Clinical Pharmacology Unit.To investigate whether these human experimental pain models can discriminate the analgesic effects of a single oral dose of Tramadol…

Effects of vibrating insoles on balance in diabetic neuropathy. Research into the optimal characteristics of the applied noise signal.

The objective of this study is to compare the effects of noise with different characteristics on balance in patients with diabetic neuropathy

The effectiveness of plantar pressure assessment and monitoring in prescription footwear to reduce re-ulceration in diabetic patients: a randomised controlled trial

To what extent does the use of therapeutic footwear, which is prescribed and monitored using plantar pressure distribution assessment, result in a reduced plantar ulcer recurrence rate compared to the use of therapeutic footwear which is prescribed…

Neuropathic Pain: development and validation of a clinical prediction rule

Primary: to develop and validate a clinical prediction rule to predict a favourable or unfavourable disease course for NP patients, therewith enabling tailor made treatments for NP patients.Secondary: determine prevalence of clinical signs of NP in…

Prevention of Phantom Limb Pain After Transtibial Amputation (PLATA) - Randomized, double-blind, controlled, multi-center trial comparing Optimized intravenous pain control vs Optimized intravenous pain control plus Regional anesthesia

The aim of this study is to test the hypothesis that a combination of optimized intravenous pain therapy and continuous sciatic nerve block decreases the point prevalence of phantom limb pain 12 months after transtibial amputation for peripheral…

Individually optimized rocker profile and self-adapting insole to reduce the plantar peak pressure in Diabetic patients with loss of protective sensation

Offloading the peak plantar pressure in Diabetic patients with loss of protective sensation by using the self-adjusting insoles and individually optimized rocker profiles. The secondary objective is to evaluate the effect of the self-adjusting…

The effect of hilotherapy on chemotherapy-induced peripheral neuropathy in the treatment of breast cancer with Paclitaxel.

Investigate the effect of hilotherapy on the severity of CIPN and nail toxicity, and its influence on treatment management and quality of life in patients with breast cancer during, and three and six months after treatment with Paclitaxel.

Randomized controlled trial of controlled hand/foot cooling to prevent neuropathy and preserve quality of life in adults treated with oxaliplatin.

This randomized phase II open label study examines the effect of controlled cooling versus no cooling on the incidence and severity of oxaliplatin-induced peripheral neuropathy (OIPN) in patients treated with oxaliplatin.