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A PHASE I, SINGLE-CENTRE, RANDOMIZED, DOUBLE-BLIND, PLACEBO CONTROLLED, SINGLE- AND MULTIPLE ASCENDING-DOSE STUDY TO EVALUATE THE SAFETY, TOLERABILITY AND PHARMACOKINETICS OF GRC 10693 IN HEALTHY MALE SUBJECTS

The study has three objectives. Firstly, we will study the safety and tolerability of the drug after the administration of both single and multiple doses of the drug. Secondly, we will study the speed at which the drug is absorbed in the body, as…

The long-term effect of the babysitterprocedure after proximal nerve injury.

Aim of this study was to assess the long term effects of the babysitter procedure in patients with proximal nerve injury.

Thresholds and localisation for mechanical stimuli in allodynia. A reproducibility study.

Objective: This study design aims to give insight in the reproducibility of a new method of testing static and dynamic stimuli with Von Frey monofilaments, as well as acquiring information on the ability to localise stimuli in CRPS patients

A SINGLE-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSSOVER PILOT STUDY WITH TRAMADOL TO VALIDATE TWO EXPERIMENTAL HUMAN PAIN MODELS AT THE KENDLE CLINICAL PHARMACOLOGY UNIT

To evaluate and implement the cutaneous electrical stimulation pain model at the Kendle Clinical Pharmacology Unit.To investigate whether these human experimental pain models can discriminate the analgesic effects of a single oral dose of Tramadol…

Randomized, double-blind, placebo-controlled study of the tolerability and pharmacokinetics of ascending single (TDU6964) and 14-day repeated (TDR6966) oral doses of SAR501788 and pilot food variability evaluation (FED6965) in healthy young male subjects - Tolerability and pharmacokinetics of 14-day repeated oral doses of SAR501788 in healthy elderly male and female subjects (TDR6967)

to assess the tolerability and safety after single oral ascending doses of SAR501788 in healthy young male subjects (Part 1)to assess the tolerability and safety after repeated oral ascending doses of SAR501788 in healthy young male subjects (Part 3…

Extensive neurophysiological investigation in Guillain-Barré patients, focussing on motor unit abnormalities and weakness

1)To determine the contribution of reversible dysfunction of nerve terminals to weakness 2) To identify electrophysiological patterns that improve classification of GBS patients, and that discriminate between patients with good and poor prognosis 3…

Effect of Spinal Cord Stimulation in Painful Diabetic Polyneuropathy (PDP study) A pilot study

1) The objective of this study is to confirm the hypothesis that SCS leads to pain relief as indicated by the results of two former pilot studies (Tesfaye et al. 1996 and Vos et al. 2008). 2) The practical feasibility of the test procedures…

Does speech therapy improve the subjective function of the inferior alveolar nerve after a permanent paresthesia due to an advancement procedure of the mandible.

Improvement of the discomfort of the paresthesia, as experienced by the patient.

Treatment of Complex Regional Pain Syndrome type I;A randomised, double-blind, placebo-controlled study with multiple rounds of S(+)-ketamine infusions (The Ket Ket Study)

Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…

Unravelling the etiology of chronic idiopathic axonal polyneuropathy

Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…

Efficacy of a thumb opponens splint on manual dexterity in patients with Hereditary Motor and Sensory Neuropathy: a pilot study

Purpose of this study is to assess the feasibility, tolerability of a short thumb opposition splint and the initial efficacy of this splint on manual dexterity and perceived limitations in activities in patients with HMSN1a. Additionally, the…

Modifiers in PMP22 related neuropathies

The objective is to determine the disease severity in genetically proven CMT1A/HNPP patients and to correlate this with sequence variants in CMT and immunity related genes. Identification of genotype-phenotype correlations in CMT1A will allow…

Chemotherapy induced peripheral neuropathy outcome measures standardisation study

Primary Objective: To define a core set of measures that meet clinimetric properties for being simple, valid, and reliable in CIPN.Secondary objectives: To develop an Overall Disability Sum-Score (ODSS) specific to CIPN; To develop a Responsiveness…

Emotional modulation of pain perception in experimental and clinical neuropathy: an fMRI study.

It is therefore planned to study pain perception in peripheral neuropathy in the context of positive and negative emotional stimulation. Although there is a recent plea for the study of emotional modulation of pain, only one study has as yet done so…

The anterior cutaneus nerve entrapment syndrome (ACNES). Randomized double blind controlled trial for the diagnosis and treatment of entrapment of the anterior cutaneus nerve through the rectus muscle.

Evaluation of the effect ofdiagnostic and therapeutic proces in reducing pain in patients suspected with ACNES.Is injection of lidocaine in patients suspected of ACNES leading to a larger group of people with a clinically relevant reduction of pain…