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Frozen gloves for prevention of chemotherapy-induced peripheral neuropathy

The primary objective is to evaluate the effectivity of frozen gloves during chemotherapy in the prevention of neurotoxicity and thereby the influence on the quality of life in patients treated with oxaliplatin, paclitaxel or docetaxel.

Neurogenic inflammation in diabetic polyneuropathy and Charcot neuro-osteoarthropathy: response to intracutaneous Candida albicans

To study the inflammatory response (induration) to intracutaneous Candida albicans in healthy individuals, patients with diabetes without polyneuropathy, patients with diabetic polyneuropathy and patients with a history of Charcot neuro-…

Effects of ARA 290 on the regrowth of epidermal nerve fibers in normal volunteers and patients with sarcoidosis

In this study we will assess the effect of ARA290 on nerve damage by taking 4 skin bipsies during treatment.

A study to investigate the pharmacodynamics, safety and tolerability of cutaneous capsaicin in healthy adult subjects.

-To investigate the feasibility, applicability, safety, tolerability, and reproducibility of addition of the capsaicin-heat model and the thermal grill to the existing nociceptive pain test battery in healthy subjects.-To investigate the feasibility…

Morphological and functional changes of the median nerve after neurolysis for carpal tunnel syndrome

The objectives of this study are twofold:1. To describe morphological and functional changes of the median nerve after neurolysis using US and NCS. 2. To correlate the morphological and functional changes to the clinical symptoms and signs

A randomized, single-center, double-blind, placebo-controlled, 2-way cross-over, single oral administration trial to evaluate blood-borne biomarker candidates to predict NOP receptor activation using GRT6010 as NOP receptor agonist in healthy human subjects.

Primair: To assess the change in the CD11b expression in leukocytes and in plasma concentrations of nociceptin after oral single dose administration of 12 mg GRT6010 compared to placeboSecundair:To assess the difference in area of the capsaicin-…

HIDES * (HIV Indicator Diseases across Europe Study)

Implement a survey initiative to assess HIV prevalence for one or more diseases and/or conditions within a specific segment of the population not yet diagnosed with HIV and that present for care with the specific disease/condition.

Treatment of Complex Regional Pain Syndrome type 1: A randomized placebo controlled double-blind study with ARA 290, The CRPSARA Study

Study AimsPrimary Aim: This is a proof-of-concept study to evaluate the effect of ARA 290 in pain of patients with CRPS1 by means of once daily subcutaneous injection with ARA 290 for 4 weeks. Secondary Aims: * Assess the predictive effect of…

ARA 290 Intravenous-Subcutaneous crossover study in normal human volunteers - PKARA Study

To measure the PK of ARA290 when given in de SQ form

Complex Regional Pain syndrome: a (focal) small fibre neuropathy possibly related to mutations in voltage-gated sodium channels

To determine, in patients registered at our hospital having CRPS (types I) at the leg, the percentage of patients having clinical features compatible with SFN and compared to the unaffected leg (in unilateral cases) to determine possible focal or…

International GBS Outcome Study
A prospective INC study on clinical and biological predictors of disease course en outcome in GBS

The International GBS Outcome Study (IGOS) aims to identify the most important clinical and biological determinants of disease progression and recovery in GBS. This information will be used to understand the diversity in clinical presentation and…