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Does speech therapy improve the subjective function of the inferior alveolar nerve after a permanent paresthesia due to an advancement procedure of the mandible.

Improvement of the discomfort of the paresthesia, as experienced by the patient.

Treatment of Complex Regional Pain Syndrome type I;A randomised, double-blind, placebo-controlled study with multiple rounds of S(+)-ketamine infusions (The Ket Ket Study)

Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…

CHRONIC PAIN MANAGEMENT AFTER HERNIORRAPHY
PREGABALIN VERSUS PLACEBO

The primary objective of this study is to investigate whether pregabalin at a dose of 150-600 mg twice a day reduces pain in patients with chronic neuropathic pain after herniorraphy. This research question will be answered by testing of the…

The kinematics and kinetics of walking using a forefoot offloading shoe in patients with diabetes and periferal neuropathy.

The goal of this study is to compare the kinematics and kinetics of walking in a FOS with a standard shoe in diabetic neuropathic patients.

Efficacy of a thumb opponens splint on manual dexterity in patients with Hereditary Motor and Sensory Neuropathy: a pilot study

Purpose of this study is to assess the feasibility, tolerability of a short thumb opposition splint and the initial efficacy of this splint on manual dexterity and perceived limitations in activities in patients with HMSN1a. Additionally, the…

*A Two Part Phase I Study to Assess Safety, Tolerability, Systemic Exposure and Effect on Analgesia and Anaesthesia of Single and Multiple doses of TDT 077 in Healthy Older Subjects.*

Part 1A:Primary objective is to evaluate the safety and tolerability of ascending single doses of TDT 077 in healthy older male and female subjects. Secondary objective is to evaluate the systemic exposure (PK) of ascending single doses of TDT 077…

A Randomized controlled trial comparing two different immunoglobulins in the treatment of CIDP.

To investigate if:-Kiovig is at least as effective as Gammagard. (equivalence)-Kiovig has a good side effect profile for CIDP patients.-Whether patients prefer Kiovig to Gammagard.

Dose response trial of IV immunoglobulin in chronic inflammatory demyelinating polyradiculoneuropathy

The primary objective is:1. To investigate whether high frequency low dosage IVIg treatment is more effective than low frequency high dosage as maintenance treatment for CIDP. Secondary objectives are:2. To investigate whether high frequency low…

Efficacy, safety and tolerability of lacosamide in patients with gain-of-function Nav1.7 mutations related small fiber neuropathy: a randomized, double-blind, placebo controlled, crossover trial

Study Rationale and ObjectivesThe objective of the study is to determine the efficacy and safety of lacosamide, a sodium channel blocker, in patients with pain due to SCN9A-associated SFN. The proposed study plans to recruit patients with clinically…

Venlafaxine for prevention of oxaliplatin-induced peripheral neuropathy - A randomised clinical trial

Given the significant number of patients with OIPN and the possible prophylactic properties of venlafaxine, this study is designed. This study will consist of a randomised placebo-controlled clinical trial to study the prophylactic effect of…

A Randomized Controlled Trial to Evaluate the Efficacy of Pulsed Radiofrequency as a Treatment for Anterior Cutaneous Nerve Entrapment Syndrome in comparison to Anterior Neurectomy

Primary objective is to study the number of patients gaining at least 50% pain reduction within 8 weeks following PRF as compared to following a neurectomy. Pain intensity will be measured using numeric pain rating score (NPRS, 0-10) and Verbal…

Follow-up of carpal tunnel syndrome

We aim to investigate the amount of patients who have lasting benefit from such surgery, and which proportion eventually get recurrent symptoms. We are going to investigate the cohort which has previously been studied by our group (protocol Dr.…

Pain and patient-reported outcome associated with surgery for carpal tunnel syndrome or trigger finger under local anesthesia with and without tourniquet

The aim of this study is to compare pain or discomfort during the ingreep between WALANT and tourniquet use.In addition, we aim to determine whether carpal tunnel release or trigger finger release using WALANT has an effect on recovery, patient-…

Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

A Randomized, Open label, Non-inferiority trial on the efficacy of Lacosamide versus Duloxetine in Patients with Chemotherapy-induced Polyneuropathy - a strategy trial

This study has been transitioned to CTIS with ID 2024-511008-17-00 check the CTIS register for the current data. To assess whether lacosamide is as efficient in the treatment of chemotherapy-induced neuropathic pain as duloxetine

Multicenter, open*label, phase II study in patients with monoclonal
gammopathy of unknown significance (MGUS) and anti Myelin Associated
Gycoproteine (MAG) Neuropathy and Zanubrutinib Treatment * MAGNAZ trial

Main objective:To improve the functional neurological outcome of patients, as measured on the Raschbuilt Overall Disability Scale (RODS) for inflammatory neuropathies (iRODS) with Zanubrutinib in combination with standard treatment with Rituximab or…

Treating Leg Symptoms in Women with X-linked Adrenoleukodystrophy: A Key to Improving Sleep and Gait Performance

This study has been transitioned to CTIS with ID 2024-518989-27-00 check the CTIS register for the current data. Objective: Primary Aim (PHASE 1):To determine the prevalence of RLS in women with ALD.Secondary Aim (PHASE 2):To determine whether in a…

The influence of a pain education program on pain perception and psychosocial functioning in
patients with complex regional pain syndrome

1. Mapping the effects of pain education on pain perception and psychosocial functioning of patients with CRPS.2. Further optimize the quality of care for patients with CRPS by further exploring the possibilities of a pain education program.

Elektrical Direct Stimulation of Peripheral Nerves to enhance Regeneration - Safety & Feasibility

The primary objective of the present study is to explore the safety and feasibility of electrical stimulation in patients with diverse kinds of nerve lesions. The secondary objective is to make a reasonable estimation of clinical effect size, which…

Conventional vascular closure device vs Statseal hemostasis: Comparing the effects on hand sensibility for radial hemostasis

Prevention of diminished hand sensibility (and secondary: hand function) after trans radial access coronary angiography by shorter wrist compression time using Statseal hemostasis.