223 results
-To evaluate the effects of IVIg on the humoral and cellular immune system.-To identify biomarkers which are associated with the effect (on muscle strength and sensory modalities) of IVIg. To investigate the value of these biomarkers in other…
Improvement of the discomfort of the paresthesia, as experienced by the patient.
Primary aim:The primary aim of this study is to evaluate the effect of two consecutive infusions of S(+)-ketamine in patients with CRPS-I on pain relief. The design of the study is prospective, randomised, double-blind and placebo-controlled.…
The primary objective of this study is to investigate whether pregabalin at a dose of 150-600 mg twice a day reduces pain in patients with chronic neuropathic pain after herniorraphy. This research question will be answered by testing of the…
The objectives of the study are:1) To evaluate the prevalence of secondary impairments and to evaluate the limitations in activities related to severity of impairments and restritions in participation in leprosy patients in the Netherlands.2) To…
To construct an optimal diagnostic protocol enabling general practitioners to distinguish between dizzy elderly patients who need treatment, dizzy elderly patients who need further diagnostics and dizzy elderly patients who need no further…
The goal of this study is to compare the kinematics and kinetics of walking in a FOS with a standard shoe in diabetic neuropathic patients.
The general aim of this pilot study is to assess the feasibility of using the Vincent 50 foot scanner for the acquisition, diagnosis, and referral of foot problems in the home environment in diabetic patients at high risk of ulceration.Specific aims…
Objectives1. Achieve a complete ascertainment of incident CIAP patients in the middle of the Netherlands during a three-year period and determine the frequency of CIAP.2. Establish whether CIAP is associated with the metabolic syndrome, and if so,…
Purpose of this study is to assess the feasibility, tolerability of a short thumb opposition splint and the initial efficacy of this splint on manual dexterity and perceived limitations in activities in patients with HMSN1a. Additionally, the…
The objective is to determine the disease severity in genetically proven CMT1A/HNPP patients and to correlate this with sequence variants in CMT and immunity related genes. Identification of genotype-phenotype correlations in CMT1A will allow…
Primary Objective: To define a core set of measures that meet clinimetric properties for being simple, valid, and reliable in CIPN.Secondary objectives: To develop an Overall Disability Sum-Score (ODSS) specific to CIPN; To develop a Responsiveness…
Part 1A:Primary objective is to evaluate the safety and tolerability of ascending single doses of TDT 077 in healthy older male and female subjects. Secondary objective is to evaluate the systemic exposure (PK) of ascending single doses of TDT 077…
To investigate if:-Kiovig is at least as effective as Gammagard. (equivalence)-Kiovig has a good side effect profile for CIDP patients.-Whether patients prefer Kiovig to Gammagard.
It is therefore planned to study pain perception in peripheral neuropathy in the context of positive and negative emotional stimulation. Although there is a recent plea for the study of emotional modulation of pain, only one study has as yet done so…
Evaluation of the effect ofdiagnostic and therapeutic proces in reducing pain in patients suspected with ACNES.Is injection of lidocaine in patients suspected of ACNES leading to a larger group of people with a clinically relevant reduction of pain…
The objective is to get insight in the pathophysiology of small fibre neuropathy in Fabry patients. Insight in the pathophysiology will be obtained by:1. Describing results obtained by the QST protocol, skin biopsies and autonomic function tests in…
To clarify the pathophysiological substrates of residual weakness and fatigue
To what extent does the use of therapeutic footwear, which is prescribed and monitored using plantar pressure distribution assessment, result in a reduced plantar ulcer recurrence rate compared to the use of therapeutic footwear which is prescribed…
1. To evaluate the diagnostic value of the short form QST protocol and skin biopsy in ISFN, and to evaluate the diagnostic value of the small fibre neuropathy screening list (developed by Hoitsma et al) in patients with other causes of SFN than…