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*Characteristics of Quantitative Sensory Testing in ACNES patients compared to healthy controls; a pilot study.*

To assess variation in and between a small cohort of ACNES patients and healthy human volunteers.

Sensory axons in multifocal motor neuropathy (MMN)

To assess if resting membrane potential or ion channel activity is abnormal in sensory axons of affected nerves in MMN patients.

MRI for MMN and CIDP - Towards improved diagnostic accuracy and dissection of pathophysiology.

1. To study reproducibility of a qualitative scale for abnormality of brachial plexus MRI.2. To study usefulness of quantification of nerve size using maximum intensity projection techniques (MIP) , and compare results with HRUS of the brachial…

Pain and patient-reported outcome associated with surgery for carpal tunnel syndrome or trigger finger under local anesthesia with and without tourniquet

The aim of this study is to compare pain or discomfort during the ingreep between WALANT and tourniquet use.In addition, we aim to determine whether carpal tunnel release or trigger finger release using WALANT has an effect on recovery, patient-…

Electrical Brain Responses During Processing of Nociceptive Stimuli Around Detection Threshold: an Explorative Study in Pain Patients

The aim of this study is to combine measurements of the NDT with EEG recording and analysis to observe neurophysiological activity during nociceptive processing in CRPS patients. In this explorative study, multiple types of stimuli are delivered.…

Quantifying various effects of closed-loop Spinal Cord Stimulation (SCS) on pathophysiological mechanisms in Complex Regional Pain Syndrome (CRPS); an explorative study

To evaluate and quantify the various clinical effects of closed-loop SCS versus open-loop SCS on the underlying pathophysiological effects in CRPS.

Functioning of the HPA-axis in patients with Complex Regional Pain Syndrome

1. To explore the complex relation between CRPS, functioning of the HPA-axis and inflammatory activation of the immune system.2. To assess associations between the HPA-axis and psychosocial determinants. 3. To explore the possible role of…

A Randomized, Open label, Non-inferiority trial on the efficacy of Lacosamide versus Duloxetine in Patients with Chemotherapy-induced Polyneuropathy - a strategy trial

This study has been transitioned to CTIS with ID 2024-511008-17-00 check the CTIS register for the current data. To assess whether lacosamide is as efficient in the treatment of chemotherapy-induced neuropathic pain as duloxetine

Multicenter, open*label, phase II study in patients with monoclonal
gammopathy of unknown significance (MGUS) and anti Myelin Associated
Gycoproteine (MAG) Neuropathy and Zanubrutinib Treatment * MAGNAZ trial

Main objective:To improve the functional neurological outcome of patients, as measured on the Raschbuilt Overall Disability Scale (RODS) for inflammatory neuropathies (iRODS) with Zanubrutinib in combination with standard treatment with Rituximab or…

Clinical assessment of women with Persistent Genital Arousal Syndrome (PGAS) by quantitative sensory testing (QST) and cornea confocal microscopy (CCM)

The primary objective of this study is to study signs of small fiber neuropathy in PGAS patients compared to healthy controls.

Treating Leg Symptoms in Women with X-linked Adrenoleukodystrophy: A Key to Improving Sleep and Gait Performance

This study has been transitioned to CTIS with ID 2024-518989-27-00 check the CTIS register for the current data. Objective: Primary Aim (PHASE 1):To determine the prevalence of RLS in women with ALD.Secondary Aim (PHASE 2):To determine whether in a…

Individually optimized rocker profile and self-adapting insole to reduce the plantar peak pressure in Diabetic patients with loss of protective sensation

Offloading the peak plantar pressure in Diabetic patients with loss of protective sensation by using the self-adjusting insoles and individually optimized rocker profiles. The secondary objective is to evaluate the effect of the self-adjusting…

The influence of a pain education program on pain perception and psychosocial functioning in
patients with complex regional pain syndrome

1. Mapping the effects of pain education on pain perception and psychosocial functioning of patients with CRPS.2. Further optimize the quality of care for patients with CRPS by further exploring the possibilities of a pain education program.

Endoscopic versus Open Cubital Tunnel Release: An Open Randomized Clinical Trial

To make an evidence-based recommendation on which method has the best efficacy (PROM), patient treatment experience (PREM) and safety profile (complications).

Elektrical Direct Stimulation of Peripheral Nerves to enhance Regeneration - Safety & Feasibility

The primary objective of the present study is to explore the safety and feasibility of electrical stimulation in patients with diverse kinds of nerve lesions. The secondary objective is to make a reasonable estimation of clinical effect size, which…

Conventional vascular closure device vs Statseal hemostasis: Comparing the effects on hand sensibility for radial hemostasis

Prevention of diminished hand sensibility (and secondary: hand function) after trans radial access coronary angiography by shorter wrist compression time using Statseal hemostasis.

Cannabis-opioid interaction in the treatment of fibromyalgia pain - an open label proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodon combination.;substudy: follow-up vragenlijst

The main objective is to assess whether Bediol (containing THC and CBD) co-treatment will reduce opioid side effects in chronic pain patients. A secondary objective will be that Bediol is superior to oxycodone in the relief of chronic fibromyalgia…

QLIPP-CIPN: Effectiveness of online Acceptance and Commitment Therapy for pain interference in cancer survivors with chronic painful chemotherapy-induced neuropathy (CIPN)

The goal of this study is to examine the effectiveness of an online psychological intervention based on Acceptance and Commitment Therapy (ACT) in a Randomized Controlled Trial (RCT) and compared to a treatment-as-usual control condition (TAU). We…

Adapted modified Toronto Clinical Neuropathy Score validated by quantitative sensory testing and nerve conduction studies for renal transplant recipients

Primary objective:To validate the adapted modified Toronto Clinical Neuropathy Score (amTCNS) with quantitative sensory testing and nerve conduction studies. Hypothesis: a. Quantitative sensory testing is correlated to the amTCNS indicating that…

The effect of hilotherapy on chemotherapy-induced peripheral neuropathy in the treatment of breast cancer with Paclitaxel.

Investigate the effect of hilotherapy on the severity of CIPN and nail toxicity, and its influence on treatment management and quality of life in patients with breast cancer during, and three and six months after treatment with Paclitaxel.