64 results
The aim of this pilot study is to investigate if DRG stimulation can evoke motor reactions in the lower extremities in patients who have already been implanted with a DRG stimulator to treat neuropathic pain.
Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…
The primary objectives are: 1) to systematically compare four brain stimulation methods and different signal processing techniques and select the best method for eventual development of a discrete brain-machine interface that allows the translation…
Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…
To determine long-term radiological and clinical outcome of a muscle-sparing surgical technique for posterior decompression of the cervical spinal cord (cervical split laminectomy).
To compare the efficacy of early decompressive surgery to improve functional outcome in patients with cevical incomplete cord lesion without a fracture or instability of the cervical spine compared to those receiving conservative treatment.
Primary: To determine the response of 2B3-101 treatment as single agent or in combination with trastuzumab in patients with LM from breast cancer using the LM response scoreSecundary: - To determine the safety profile in patients with LM treated…
The purpose of this study is to observe the usability of Dexmedetomidine and to determine the overall satisfaction of the patient.
Dorsal column stimulation and dorsal root ganglion stimulation are both proven to be effective as treatment for chronic, neuropathic pain. We want to compare patients preference of stimulation type in patients with chronic, neuropathic pain due to…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…
The primary objective is to evaluate the short- and long-term effectiveness of a hybrid cycle training program on physical capacity, active lifestyle, participation, and quality of life among a group of inactive individuals with a chronic SCI.…
1) To study the effect of Clonidine on lumbar radicular pain with a transforaminal epidural injection after 1 week, 1, 3 and 6 months using a BPI.2) To study the effect of Clonidine on lumbar radicular pain with a transforaminal epidural injection…
The primary objective is to evaluate the effectiveness of low-intensity hand rim wheelchair exercise training on physical capacity, daily (wheelchair) functioning, participation and quality of life in people with a spinal cord injury. Furthermore,…
Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.
The aim of this project is to assess the feasibility of the technology assisted training to improve arm hand skilled performance using the Haptic Master in persons with C-SCI.Research questions:Is it feasible to train persons with a C-SCI with a…
To evaluate the feasibility of PENS in patients with chronic neuropathic pain due to SCI.
The Sciatica-Gill trial is a randomised cost-effective study about nerve root decompression according to Gill versus instrumented fusion in the treatment of patients with radicular legpain or neurogenic claudication due to spondylolytic…
The trial is designed as an open-label pilot study. The main goal is to investigate if bezafibrate can reduce VLCFA in vivo in patient with X-ALD. If there is indeed a biochemical effect, a large follow-up study will be initiated with clinical…
To show that an individually tailored treatment of the calf muscles with BTX-A promotes the balance capacity and mobility of HSP patients by an effective reduction of spasticity while preserving muscle strength. This explorative study uses a pre-…