120 results
The aim of this pilot study is to investigate if DRG stimulation can evoke motor reactions in the lower extremities in patients who have already been implanted with a DRG stimulator to treat neuropathic pain.
The aim of this study is to compare the effects of anterior cervical discectomy versus percutaneous plasma discectomy on pain, on global perceived effect, functional status and health-related quality of life in a group of patients with cervical…
The purpose of this study is to observe the usability of dexmedetomidine compared to the standard therapy (propofol) and to determine the overall satisfaction of the patient.
Documentation of the patients' functional recovery and quantification of fusion after implantation of 3-D trabecular titanium cages on the short and long term. These data will be compared with the recently performed randomized CASCADE trial on…
The primary objectives are: 1) to systematically compare four brain stimulation methods and different signal processing techniques and select the best method for eventual development of a discrete brain-machine interface that allows the translation…
Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…
To determine long-term radiological and clinical outcome of a muscle-sparing surgical technique for posterior decompression of the cervical spinal cord (cervical split laminectomy).
The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…
To compare the efficacy of early decompressive surgery to improve functional outcome in patients with cevical incomplete cord lesion without a fracture or instability of the cervical spine compared to those receiving conservative treatment.
Primary: To determine the response of 2B3-101 treatment as single agent or in combination with trastuzumab in patients with LM from breast cancer using the LM response scoreSecundary: - To determine the safety profile in patients with LM treated…
The purpose of this study is to observe the usability of Dexmedetomidine and to determine the overall satisfaction of the patient.
Dorsal column stimulation and dorsal root ganglion stimulation are both proven to be effective as treatment for chronic, neuropathic pain. We want to compare patients preference of stimulation type in patients with chronic, neuropathic pain due to…
A study on extent-related outcome and complications for degenerative cervical spinal disease has not yet been performed. Results of this study may form the basis for a guideline regarding the extent of fixation in degenerative cervical spinal…
Primary Objective: Evaluate the functional integrity of the nociceptive system after percutaneous cervical chordotomy using Laser Evoked Potentials Secondary Objective(s): change in opioid consumption after percutaneous cervical chordotomy using a…
The primary objective of the study is to evaluate the safety and tolerability of a range of single IV and SC doses of BG00010 in healthy volunteers, and a range of multiple SC doses of BG00010 in subjects with painful lumbar radiculopathy.Secondary…
Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…
The purpose of the this study is to evaluate the prognostic capabilities of biomarkers in CSF in patients with SCI.
Aim of the study is to evaluate if the optical tissue stylet technology can discriminate tissues that are relevant to recognize for interventional pain procedures.
The purpose of this trial is to demonstrate the superior efficacy of pudendal neuromodulation in treating patients with neurogenic overactive bladder, who have failed conservative treatment, in a randomized cross-over trial.Symptoms of urinary…
The primary objective of the study is to evaluate the safety, tolerability, and pharmacokinetic (PK) profile of 3 intravenous (IV) injections of BG00010 given on 2 fixed schedules; weekly and as frequently as every 48 hours (but no more than 3 times…