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Step-down versus step-up analgesics in patients with (sub)acute sciatica in primary care

Primary Objective:What is the effectiveness of immediate opioid pain medication (followed by step-down) versus step-up pain medication within the treatment according general practitioners* clinical guideline in patients with (sub)acute sciatica,…

Sensation in children with an Obstetric Brachial Plexus Palsy

The main objective is to investigate if the sensation of children with an upper OBPL is diminished. Both children that were treated conservatively as children that were surgically treated with nerve surgery in early infancy.The primary research…

Dexmedetomidine in awake implantation of neuromodulative systems.

The purpose of this study is to observe the usability of Dexmedetomidine and to determine the overall satisfaction of the patient.

Comparing patient's preference of dorsal column stimulation versus dorsal root ganglion stimulation in patients with complex regional pain syndrome confined to the knee

Dorsal column stimulation and dorsal root ganglion stimulation are both proven to be effective as treatment for chronic, neuropathic pain. We want to compare patients preference of stimulation type in patients with chronic, neuropathic pain due to…

The CHARACTER SCS Study: A randomised pilot study to assess differenCes in tHe subjects* experience of stimulAtion-Induced paRaesthesiA between two different spinal Cord sTimulation dEvices: the Axium® DoRsal Root Ganglion Stimulation System Versus the Prime Advanced* Dorsal Column Stimulation System

The principal goal of this study is to compare subjects* experience of Spinal Cord Stimulation (SCS) with two different types of SCS device.

Performance attributes and user progression while using Ekso Robotic Exoskeleton in an eight week, over ground, locomotor program in individuals with spinal cord injury

Primary objective is to evaluate the performance attributes and user progression of participants with motor complete and incomplete SCI while utilizing the Ekso robotic exoskeleton in an eight week over ground, locomotor program. Secondary objective…

Effects of Lumbar Sympathetic Blockade Renal Plasma Flow and Glomerular Filtration Rate.

With this study we will investigate the effects of lumbar sympathetic blockade on ERPF and measured GFR and relative changes in non - invasive hemodynamics measured before and after continuous lumbar sympathetic blockade or splanchnic blockade in…

Cost-effectiveness of minimal invasive spinal fusion compared to open fusion for patients with spinal stenosis with neurogenic claudication or radicular leg pain.

What is the cost-effectiveness of minimal invasive posterior lumbar interbody fusion in spinal stenosis patients, compared to the standard open fusion?

A multicenter, prospective, randomized, placebo-controlled, double-blind, parallel-group clinical trial to assess the efficacy and safety of Immune Globulin Intravenous (Human) Flebogamma® 5% DIF in patients with Post-Polio Syndrome

To test whether monthly infusions (every four weeks) of intravenous Flebogamma® 5% DIF in a 1 year treatment period in PPS subjects are superior to placebo by assessing physical performance, as measured by 2MWD.For Stage 1, to select the optimal…

Minimally Invasive Surgery versus Open Surgery (MISOS) in the treatment of spondylolisthesis; a randomised controlled trial.

To document whether patients treated with minimally invasive surgery experience less back pain at 2 and 6 weeks after surgery, compared to patients treated with conventional open instrumented surgery.

Effect of trans-spinal direct current stimulation and robotic support on the neural motor pathways in healthy and SCI subjects.

The primary objective is to assess the neural short term changes, robotic gait therapy and tsDCS have on the corticospinal pathways. Thereby it has to be investigated in what kind of configuration and intensity tsDCS is most effective as well as…