67 results
Protocol page 17The Mapping for Transvenous Phrenic Nerve Stimulation Study (MAPS) is being conducted to evaluate the feasibility of transvascular stimulation of phrenic nerves via an EP catheter advanced into the great veins.
FT218 is a new formulation (composition) of the registered drug sodium oxybate. Sodium oxybate (also known as the sodium salt of gamma-hydroxybutyric acid [GHB]) is registered under the name Xyrem® for the treatment of narcolepsy (excessive…
The current research is set to provide insight into the phenotypic characteristics of DSPD patients in terms of psychological characteristics, occurrence of co-morbidities, and behavioural characteristics such as bedtime routines and lifestyle, and…
The aim of this study is primarily to investigate the effects of a withdrawal intervention on measures of driving performance in a clinical population that uses benzodiazepines, Z-hypnotics, or opioid analgesics chronically. As a secondary objective…
To investigate the incidence and severity of disturbed biorhythm among ICU patients, and the effect on quality of sleep. We also aim to validate the novel ICU Depth Of Sleep (IDOS) index in detecting depth of sleep over time. Secondarily: we will…
FT218 is a new formulation (composition) of the registered drug sodium oxybate. Sodium oxybate (also known as the sodium salt of gamma-hydroxybutyric acid [GHB]) is registered under the name Xyrem® for the treatment of narcolepsy. The purpose of…
During the study, an oral solution of JZP-507 produced on a commercial scale will be compared with a JZP-507 oral solution produced on a pilot scale (an oral solution of JZP-507 which is manufactured locally at PRA). The purpose of the study is to…
The purpose of the study is to investigate how quickly and to what extent 2 different production batches of FT218 (batch A and batch B) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…
Primary aim is to validate the SART as a screenings instrument for driver fitness in patients with narcolepsy and idiopathic hypersomnia.
With this study we aim to investigate the emotional development, behavior, social behavior, variation in personality traits and intellectual functioning in a group of children who are diagnosed with narcolepsy with of without cataplexie, according…
No studies have yet investigated brain activity in NC patients in relation to alertness and sleep resistance. The aim of the current study is to obtain more insight into the regulatory mechanisms controlling alertness and sleep resistance in…
The aim of this study is to investigate the differences between RLS and PLMS.
The first objective of this study is to investigate the feasibility of performing home sleep EEG registrations in older people with intellectual disability. The second objective of this study is the determine which sensitivity setting of the Sleep…
We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…
The goals of the present study, therefore, are twofold:a) To estimate the incidence of dream/reality confusions in the narcoleptic population, relative to healthy controlsb) To provide a comprehensive description of the characteristics of these…
Primary:• To study the effect of rotigotine on nocturnal hypokinesiaSecondary:• To study the possibility of measuring nocturnal hypokinesia and its severity in a home setting• To correlate improvements in sleep quality by rotigotine with changes in…
Objective: In this pilot study experience will be obtained in the simultaneous use of PSG, melatonin assay, CBT-measurement and assessment in ICU patients.
The main objective is to determine whether a 5-day intervention of daily timed physical exercise improves sleep parameters and is capable of resetting the circadian clock in patients with DSPD. The secondary objectives are to compare the efficacy of…
To understand the neurocognitive mechanism underlying food-related motivation and control in patients with narcolepsy with cataplexy.
Determination of SDB prevalence in patients after strokeDetermination of the relationships between SDB (in particular OSAS) and complants of fatigue and complaints of emotional and cognitive disturbances in patients who experienced a stroke.…