26 results
The current research is set to provide insight into the phenotypic characteristics of DSPD patients in terms of psychological characteristics, occurrence of co-morbidities, and behavioural characteristics such as bedtime routines and lifestyle, and…
To investigate the incidence and severity of disturbed biorhythm among ICU patients, and the effect on quality of sleep. We also aim to validate the novel ICU Depth Of Sleep (IDOS) index in detecting depth of sleep over time. Secondarily: we will…
Primary aim is to validate the SART as a screenings instrument for driver fitness in patients with narcolepsy and idiopathic hypersomnia.
The aim of this study is to investigate the differences between RLS and PLMS.
We aim to establish whether our judgment of *misperception* is really doing justice to the condition paradoxical insomniacs suffer from. We should keep in mind that our present definition of sleep, based on the standardized polysomnographic scoring…
The goals of the present study, therefore, are twofold:a) To estimate the incidence of dream/reality confusions in the narcoleptic population, relative to healthy controlsb) To provide a comprehensive description of the characteristics of these…
Determination of SDB prevalence in patients after strokeDetermination of the relationships between SDB (in particular OSAS) and complants of fatigue and complaints of emotional and cognitive disturbances in patients who experienced a stroke.…
The aim of this study is to examine if an increased number of awakenings in PTSD is PTSD dependent or trauma dependent. Furthermore, the purpose of the study is to examine if the nocturnal excretion of cortisol is increased.
The current study assesses activation of hippocampus and prefrontal cortex during sleep spindles in veterans with and without PTSD. Furthermore, the correlation between sleep spindles and memory consolidation will be examined.
This study aims to further clarify the pathophysiological mechanisms underlying the decreased vigilance, sleep/wake lapses, and the emotional processing leading to cataplexy.
Is the muscle weakness during cataplexy due to pre- or postsynaptic inhibition? In other words: what happens with the H-reflex and Magnetic Evoked Potential during REM sleep and cataplexy?
1. To compare energy expenditure in detail between narcolepsy patients and healthy controls. 2. To compare insulin sensitivity between patients with narcolepsy and healthy controls.3. To establish the impact of chronic sodium oxybate treatment (3-4…
The aim of this study is to examine arousals in PTSD, and to investigate the correlation of arousals with nocturnal excretion of hormones of the HPA-axis.
The aim of this study is to seek evidence that such cyclic suppression exists. For this purpose, we will use the Hoffmann- or H-reflex, an electrically evoked reflex. By stimulating the tibial nerve in the knee, the alpha motor neuron in the spinal…
Our objective is to investigate decision-making in people with narcolepsy with and without cataplexy and compare it to that of age-and sex-matched healthy controls using psychometric testing, subjective and objective sleepiness tests and the Balloon…
The aim of this longitudinal study is to find new biological, clinical and/or electrophysiological biomarkers in order to define and differentiate individual diagnoses of NT1 and the NBL, and to find improved treatment targets and strategies.
The objective of the study is to investigate whether adding i-CBT-I at the start of standard pain treatment can enhance pain healthcare by reducing patient suffering and costs compared to Treatment As Usual (TAU). Our analyses will examine whether…
To investigate in people with NT1 and matched controls, after an experimentally induced social stress test:Primary:- Direct HPA activation (plasma cortisol).Secondary: - Direct autonomic stress response (ACTH and HR). - HPA activity and autonomic…
To identify novel (causal) risk factors, including biomarkers and genetic determinants for disease progression and (severe) diabetes complications in people with T2D, in order to develop new, more targeted and effective therapies that will improve…
The objective of this study is to identify clinical and non-invasive neuroimaging markers that are characteristic for RBD in PD and DLB.