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A Randomized, Double-Blind, Placebo-Controlled, Multiple Rising Oral Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TAK-994 in Patients With Narcolepsy With or Without Cataplexy (Narcolepsy Type 1 or Narcolepsy Type 2)

PART A and PART DTo assess the safety and tolerability of TAK-994 following multiple oral doses in subjects with narcolepsy with or without cataplexy (NT1 or NT2).PART B and PART C To assess the efficacy of TAK-994 on reducing excessive daytime…

An open-label, single-dose study to assess the absolute oral bioavailability and pharmacokinetics of JNJ-42847922 (seltorexant) administered as oral tablet and an intravenous microdose of 14C-seltorexant in healthy participants

In this study we will investigate how safe the new compound seltorexant is and how well it is tolerated when it is used by healthy participants.We also investigate how quickly and to what extent seltorexant is absorbed, transported, and eliminated…

Solriamfetol*s Effect on Cognitive Health in Apnea Participants During a Randomized Placebo-controlled Study (SHARP): a 5-Week Double-blind, Placebo-controlled, Randomized, Crossover, Multicenter Study of Solriamfetol in Improving Cognitive Function in Participants With Excessive Daytime Sleepiness Associated With Obstructive Sleep Apnea Plus Impaired Cognitive Function.

Primary Objective: To evaluate the effect of solriamfetol on cognitive functioning using an objective measurement. Secondary Objective:To evaluate the effect of solriamfetol on cognitive functioning using a subjective endpoint

Extensive phenotyping of REM sleep behavior disorder in patients with Parkinson*s disease and Dementia with Lewy bodies

The objective of this study is to identify clinical and non-invasive neuroimaging markers that are characteristic for RBD in PD and DLB.

Effectiveness of ketogenic diet on excessive daytime sleepiness in adults with narcolepsy type 1: a proof of concept study

This study comprises a first proof of concept. The primary aim is to investigate the effect of a ketogenic diet on EDS and sustained attention in adult NT1 patients. Secondary aims are to investigate if a ketogenic diet improves weight reduction,…