132 results
The aim of the study is to be able to estimate the long-term neurological outcomes in patients with acute severe brain injury in the acute phase. This is accomplished through additional neurological clinical studies, EEG reactivity testing, imaging…
The primary objective of this study is to assess whether the use of a compensatory brain game supported GMT treatment could be of interest in people with EF deficits after ABI, to improve goal achievement, their executive function performance during…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
Primary Objectiveo evaluate the safety and tolerability of a one-time, intrathalamic administration of AVB-101 in subjects with FTD-GRN.Secondary Objectiveo To evaluate the preliminary clinical and biomarker measures of efficacy of a one-time,…
Primary Objective: What is the effect of a transfer from home to a nursing home environment on the level of physical activity in the elderly with dementia over time? Secondary Objective(s): Is there a relationship between a possible change in the…
Our main objective is to explore the relationship between nutritional intake, growth, body composition and brain development. Hereby we want to improve our knowledge about how to feed the preterm infant in a way that contributes to a better…
We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning…
To determine whether CT optimal touch reduces pain experience in PD patients.
Understand perceptions of people with young-onset dementia and their family caregivers about quality of life, advance care planning and care including end-of-life care, and understand what professional caregivers can learn from understanding and…
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
To report on the long-term effect modification by age of MPH treatment on brain structure and function, and clinical outcome, as measured by MRI scans, neuropsychological assessment, actigraphy and questionnaires, and to compare these results with…
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
To explore the neurophysiological and functional neuroimaging effects of Zolpidem on brain function in AM patients.
Unravelling the biopsychosocial factors of fatigue and sleep complaints after traumatic brain injury
Examining the development of fatigue and sleep complaints following moderate to severe TBI and exploring the underlying causes within a biopsychosocial model. We hypothesize that biological factors are associated with sleep complaints and fatigue in…
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
This proof-of-concept study aims to non-invasively detect amyloid-beta (Aβ)-plaques in the retina of AD patients using a Heidelberg Spectralis scanner with Curcumin as labeling fluorophore. The retinal Aβ-plaques will be related to currently used AD…
To determine the difference in change over time of cognitive function and brain magnetic resonance imaging (MRI) measurements between breast cancer survivors and cancer-free individuals.
To provide more objective information regarding the integrity of residual cognitive functions in patients with DOC after severe brain injury, and to relate early-phase behavioural, EEG, and neuroimaging findings to late clinical outcome. This might…