52 results
The aim of the study is to answer the following questions:1: Is there a difference in body composition between patients with HD and matched controls?2: Does HD affect body composition differently in men and women? 3: Are changes in body composition…
The main objective of the study is to provide insight in the developmental problems of very premature and/or VLBW children compared to their term born peers, and to investigate the possible beneficial longitudinal effects of the GEEF intervention on…
Our general objective is to find out whether impaired communication within networks of specific brain regions underlies the cognitive control- and social problems of individuals with NF1. It is very important to examine these relations in children…
To study the acute effect of HD on global and regional CBF.
Our objective is to obtain insight into whether and how the visual and auditory systems of hemispherectomized patients have adapted after brain damage and brain surgery in early life. For this purpose we will perform psychophysical tests and (…
The main objectives are to understand how clinical markers and biomarkers previously identified in younger and older AD cohorts apply to the extreme elderly (90+ years old) and to identify novel biomarkers linked with resilience to developing…
Primary objective of this study: To establish glycocalyx properties of temporal lobe epilepsy (TLE) patients. Secondary objectives of this study:- To establish differences in glycocalyx properties of glycocalyx between TLE patients and controls.- To…
Primary ObjectiveOur primary objective is to investigate the effect of SVD-progression on the long-term clinical outcome. Secondary Objectives- To identify causes and risk factors related to an unfavourable clinical outcome over time- To identify…
This study has been transitioned to CTIS with ID 2024-517636-22-00 check the CTIS register for the current data. The main objective of the present study is to investigate the association between in vivo regional synaptic loss ([18F]SynVesT-1 PET),…
This study will investigate the potential value of CFX treatment, by prospective monitoring of functioning in patients that undergo this treatment. Likewise, aspects of the treatment that are important for patient experience will be systematically…
The primary objective is to evaluate longitudinal developmental changes in brain structure in patients aged 6-18 years with SCD. The secondary objective is to analyze the longitudinal relations between biomarkers, demographic characteristics, brain…
This study has been transitioned to CTIS with ID 2024-517634-17-01 check the CTIS register for the current data. The main objectives are to 1) investigate the relation between (longitudinal) tau and amyloid accumulation in cognitively normal…
The BeyeOMARKER study*s primary aim is to (1) evaluate the real-world predictive value of blood- and eye-based biomarkers for detection of AD-related clinical progression and biological changes in eye clinics. Secondly, we aim (2) to assess the…
The current study aims to obtain a better understanding of glymphatic dysfunction in dementia of the Alzheimer*s type and its preclinical stages.The main objective of this study is to improve our understanding of the potential link between…
The precise pathophysiology for hypertension causing brain damage is still unclear, although microvascular dysfunction is thought to play an important role. Therefore, in this study the small cerebral vessels will be studied in more detail. The main…
This study has been transitioned to CTIS with ID 2024-518559-41-01 check the CTIS register for the current data. The main objectives are to identify markers for amyloid pathology in cognitively normal subjects, to identify risk factors for amyloid…
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
(1) investigate alterations in executive functioning in extremely preterm-born adolescents in the Netherlands relative to term-born controls, (2) assess the neurobiological basis of individual variability in executive functioning following preterm…
We aim to assess the association between variability and irregularity in heart rate (as caused by permanent atrial fibrillation), and cognitive function. In addition, variability and irregularity of the peripheral blood pressure will be correlated…
The aim of the study is to be able to estimate the long-term neurological outcomes in patients with acute severe brain injury in the acute phase. This is accomplished through additional neurological clinical studies, EEG reactivity testing, imaging…