156 results
The main objective is to quantify neuroinflammation using [11C]SMW139 PET-scans in subjects along the AD continuum and age/sex-matched cognitively unimpaired subjects.
The purpose of this study is to evaluate the safety and efficacy of two doses of the study drug CT1812 per day for six months in subjects with mild to moderate Alzheimer's disease. CT1812 will be compared with a placebo. A placebo is a product…
Primary Objectiveo evaluate the safety and tolerability of a one-time, intrathalamic administration of AVB-101 in subjects with FTD-GRN.Secondary Objectiveo To evaluate the preliminary clinical and biomarker measures of efficacy of a one-time,…
Primary Objective: What is the effect of a transfer from home to a nursing home environment on the level of physical activity in the elderly with dementia over time? Secondary Objective(s): Is there a relationship between a possible change in the…
Our main objective is to explore the relationship between nutritional intake, growth, body composition and brain development. Hereby we want to improve our knowledge about how to feed the preterm infant in a way that contributes to a better…
We aim to develop an innovative personalized prognostic model for outcome of children with TBI, using a unique combination of demographic, pre-injury and clinical predictors. The value of innovative MRI techniques and promising machine learning…
Part 1:The purpose of this study is to determine whether LMTM inhibits monoamine oxidase (MAO). MAO is an enzyme (protein involved in reactions in the body) which breaks down tyramine. By giving participants tyramine which raises the blood pressure…
To determine whether CT optimal touch reduces pain experience in PD patients.
Understand perceptions of people with young-onset dementia and their family caregivers about quality of life, advance care planning and care including end-of-life care, and understand what professional caregivers can learn from understanding and…
To evaluate the effects of LCZ696 compared to valsartan on cognitive function over 3 years in patients with HFpEF as assessed by the CogState cognitive assessment battery.
The purpose of this study is to determine the effect of treatment on cognition, overall clinical status and underlying pathology in subjects with a risk of occurrence of the first clinical symptoms of Alzheimer's disease.People without…
Our primary objective is:i. To assess the quantity and regional distribution of [18F]DPA-714 binding as a marker of microglial activation in patients with FTD compared to controls. Our secondary objectives are: i. To compare the quantity and…
To report on the long-term effect modification by age of MPH treatment on brain structure and function, and clinical outcome, as measured by MRI scans, neuropsychological assessment, actigraphy and questionnaires, and to compare these results with…
Primary Objective: - To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors.Secondary Objective(s): - To identify specific patterns of brain…
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
To explore the neurophysiological and functional neuroimaging effects of Zolpidem on brain function in AM patients.
Unravelling the biopsychosocial factors of fatigue and sleep complaints after traumatic brain injury
Examining the development of fatigue and sleep complaints following moderate to severe TBI and exploring the underlying causes within a biopsychosocial model. We hypothesize that biological factors are associated with sleep complaints and fatigue in…
The aim of the current study is to determine whether a *liberal* strategy of maintaining Hb concentrations above 9 g/dL would result in a different neurological outcome when compared to a *restrictive* approach to red-cell transfusion to avoid…
Primary objective of the study: 1. To report on the long-term effect modification by age of MPH treatment on the outgrowth of the DA system using state-of-the-art Magnetic Resonance Imaging (MRI) techniquesSecondary objectives:1. To report on the…
This proof-of-concept study aims to non-invasively detect amyloid-beta (Aβ)-plaques in the retina of AD patients using a Heidelberg Spectralis scanner with Curcumin as labeling fluorophore. The retinal Aβ-plaques will be related to currently used AD…