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The effect of intravenous lidocaine to prevent intracranial pressure increase in endotracheal intubation assessed by optic nerve sheath diameter

Primary Objective: To investigate the effect on the distention of the ONSD while using lidocaine 1,5 mg/kg IV during endotracheal intubation versus placebo. Secondary Objectives: The secondary objective of this study is to investigate the effect…

Effect of positive transpulmonary pressures on intracranial pressure and cerebrovascular autoregulation in severe acute brain injury

The primary objective of this study is to determine the effect of changes in transpulmonary pressure on ICP in severe TBI patients. Secondary objectives are to study the effect of change in transpulmonary pressure on cerebral blood flow velocity,…