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Investigating the relationship between mobile phone usage and emotions. A pilot study using the experienced sampling method

The objective of this study is to investigate whether there is a relation between smartphone usage and psychological parameters in young adults. Taking into accordance the type of research (explorative, observational) and the present state of…

A Randomized Clinical Trial of Cutaneous Xylocaine Spray to Reduce Intravenous Cannulation Pain in Adults.

Objective: Adequate analgesia during intravenous cannulation.Hypothesis: Xylocaine spray for the placement of an infusion decreases the pain score with two or more points in comparison to placebo spray.Studie questions:Primary: Has xylocaine spray…

Deep and slow breathing in postsurgical abdominal pain management: an explorative study

To investigate whether deep and slow breathing exercises can reduce pain induced by mobilizing from bed to chair after major abdominal surgery, compared to a reading task.

Influence of alveolar tampon packing on incidence of pain and quality of life in the week following third molar surgery

The aim of this study is to assess the influence of alveolar tampon packing on incidence of pain, swelling, trismus, alveolar osteitis, and QoL in the week following M3 surgery.

Employing dynamic kinetic responses to demonstrate the effectiveness of dietary intervention: A challenge-based study using a low-glycaemic load diet

Primary objective: To assess the impact of a low glycaemic load (GL) diet as compared to a *Western* diet on metabolic flexibility (the change in RQ) upon a hyperinsulinemic euglycemic clamp. Secondary objectives: 1) To assess the impact of low GL…

From expecting to experiencing: The role of parenting cognitions in the transition to parenthood

Study 1 is aimed to describe normative trajectories of parenting efficacy from pregnancy to early parenthood. Study 2 is focused on the question whether mental representations of attachment are protective in the context of parenting stress and its…

The effect of an interdental brush and a water flosser on gingival bleeding and gingival abrasions. A 4 weeks randomized clinical trial.

Primary objective: - What is the effect of the commercially available Water Flosser compared to interdental brushes evaluating gingival bleeding in a group of systemically healthy participants with gingivitis but without periodontitis?Secundary…

Arterial stiffness, Blood Pressure and Cardiac output study; ABC-study;A Prospective, Multidisciplinary study of arterial stiffness measures in patients treated for aortic aneurysms in relation to blood pressure and cardiac output

Zie document PROTOCOL SYNOPSIS ABC study

Distinguishing awareness deficits after acquired brain injury: Validation of a clinical assessment tool in a Dutch sample.

1) Main Objective: To investigate the validity, reliability and feasibility of the Clinician*s Rating Scale for evaluating impaired self-awareness and denial of disability after brain injury (CRS-ISA-DD) for use in the Dutch clinical practice.2)…

The effect of concentrated beetroot juice with or without vitamin C on the levels of N-nitroso compounds in urine

The main aim of the study will be to compare the urinary N-nitroso compounds levels after intake of 70 ml of concentrated red beetroot juice containing 400 mg nitrate either with or without supplementation with 1 g vitamin C.

Effects of prophylactic use of haloperidol in critically ill patients with a high risk for delirium

In this study we aim to examine the effects of a low dosage of prophylactic haloperidol in patients with an expected ICU length of stay of >1 day. We use two different dosages of haloperidol in this study to compare with placebo. A dosage of…

Characterization and localization of microstructural changes in brain tissue in Neuropsychiatric Systemic Lupus Erythematosus (NPSLE)

• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…

Study to investigate the association between the response to a cholinergic challenge with galantamine and the clinical response to subsequent treatment with galantamine in patients with mild to moderate Alzheimer's Disease

We propose to conduct a study in patients with mild to moderate AD where a cholinergic challenge is given in a placebo-controlled, cross-over fashion, prior to onset of treatment with a CEI. Patients will be followed over a period of 6 months to…

Mini-internet training in positive reappraisal and concrete thinking for adolescents

This study aims to compare the effects of a training in concrete thinking and a training in positive reappraisal with a control conditions (no specific training instructions) on indices of psychological wellbeing in youth aged 15 to 18. Participants…

Children exposed to antiepileptic drugs in utero: developmental and behavioral effects in primary school children

Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…

Effects of over-the-counter lactic acid-containing vaginal douching products on the vaginal microbiota

The aim of our pilot intervention study is 1) to describe the effects of lactic acid-containing vaginal douching on the vaginal microbiota dynamics using novel molecular laboratory methods.2) to describe the effect of lactic acid-containing vaginal…

Dose response of DHA and vitamin supplements during pregnancy and lactation to increase the breast milk DHA content to 0.7-1.0 g%.

The primary aim of this study is to find the dose of DHA during pregnancy and lactation that leads to a mean breastmilk DHA of at least 0.7g%.

The LINC-study: LInking EDCs in maternal Nutrition and Child health

To relate exposure markers of EDCs to health outcomes in children - in particular obesity and neurobehavioral disorders -, effect biomarkers, and other parameters via multiple regression and multivariate analysis, while taking into account relevant…

Motor cortical control of antagonist muscle function in aging

To examine the motor cortical control of antagonist muscle function in younger and older adults

A 24 month, multicenter, randomized, open-label safety and efficacy study of concentration-controlled everolimus with reduced calcineurin inhibitor vs mycophenolate with standard calcineurin inhibitor in de novo renal transplantation- Advancing renal TRANSplant eFficacy and safety Outcomes with an eveRolimus-based regiMen (TRANSFORM)

Primary: to evaluate the effect of everolimus with reduced exposure CNI versus MPA with standard exposure CNI on the binary composite of treated biopsy-proven acute rejection (tBPAR) or eGFR < 50mL/min/1.73m2 at Month 12 post-transplantation.…