705 results
Zie document PROTOCOL SYNOPSIS ABC study
1) Main Objective: To investigate the validity, reliability and feasibility of the Clinician*s Rating Scale for evaluating impaired self-awareness and denial of disability after brain injury (CRS-ISA-DD) for use in the Dutch clinical practice.2)…
• To increase the sensitivity of the current MRI methods for detecting the changes caused by NPSLE through the scans made on the 7 Tesla scanner, since the higher field strength will lead to a higher signal to noise ratio and higher resolution. • To…
We propose to conduct a study in patients with mild to moderate AD where a cholinergic challenge is given in a placebo-controlled, cross-over fashion, prior to onset of treatment with a CEI. Patients will be followed over a period of 6 months to…
Purpose of the study is to investigate neurocognitive and behavioral development in children of morthers with epilepsy, primary school age, and who were exposed to anti-epileptic drugs in utero. Primary research questions are: 1. what is the nature…
To examine the motor cortical control of antagonist muscle function in younger and older adults
We hypothesize that stepwise dose of intravenous infusion of nitroglycerin reverses clinical abnormalities of peripheral circulation in patients with circulatory shock and that this can lead to improvement in survival rate. In addition, we expect…
to investigate the course of the pancreatic enzymes (serum amylase, serum lipase and urinary amylase) related to the course and stage of acute pancreatitis and thereby calculating the diagnostic accuracy of each pancreatic enzyme for acute…
The main objective is to improve treatment with clotting factor concentrate of patients affected by RBDs by collecting and analysing data on the patients genotype, laboratory phenotype and clinical severity.Secondary objectives are to gain…
Our main objective is the characterization and comparison of interactions/ phenotype differences in DCs, Th cells and ILC2s obtained from asthma patients with controlled, partly controlled and uncontrolled clinical symptoms and healthy controls.
The objective of this study is to explore the effects of spinal anesthesia on hemodynamic parameters of fluid status, especially vena cava inferior diameter and collapsibility. TFurthermore, the correlation between vena cava inferior collapsibility…
This study is aimed at two objectives: Objective 1: Development of new clinical fMRI protocols, based on existing cognitive tasks, that provide robust and reliable activation patterns, as well as performance measures that correlate woth…
Facilitation of translation of MR protocols from research to clinical setting.
Calibration of the mitochondrial oxygen tension technique in the human skin
For head and neck (H&N), lung and esophageal cancer, an initial simple screening test would involve interrogation of the buccal mucosa. There are several tissue alterations related to field carcinogenesis that are currently undetectable but…
Primary Objective: to determine if lactate can be continuously and reliably measured by microdialysis in subcutaneous tissue in healthy volunteers
This proof of principle study is designed to study the excretion of two well-studied transporters, Aquaporin-2 (AQP-2) and the sodium chloride cotransporter (NCC), in urinary exosomes. Both are sensitive to water homeostasis, so that during water…
To further optimize 7.0 Tesla MRI techniques and to develop new MRI techniques that will enable state-of-the-art clinical and cognitive research leading to improved patient care. Whereas some applications of 7.0 Tesla MRI already show improvements…
To develop a novel multi-parametric diagnostic model for the management of patients with LRTI and/or sepsis that will be based on novel pathogen- and host-related factors.
Does the *auto-cuff* response persist during automated consecutive blood pressure recording in patients who have been referred for out of office BP measurements as a potential explanation for the difference between HBPM (active-measurement) and ABPM…