5297 results
Primary Objective:Efficacy:· Evaluate the efficacy of subcutaneous (sc) azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in the defined study population.Secondary Objectives:Safety:· Assess the safety and…
To investigate whether there is a difference in gastric volume over time after ingestion of cow milk between lactose tolerant, habitual milk consumers reporting no GI symptoms and non-habitual milk consumers reporting GI symptoms after milk…
to assess the endodontic and restorative survival of teeth after root canal treatment and the endodontic and restorative success of the root canal treatment performed at the Special Dental Care Center of the Martini Hospital.
Primary Objective:- Long-term safetySecondary Objective:- Survival- Clinical efficacy of AUTO CAR T cell therapy in patients enrolled prior to disease progression- Chimeric antigen receptor (CAR) transgene persistence- Replication competent…
To assess the tolerance of RISA after its application in the root canal system during root canal treatment.
To compare the anabolic properties of a meal-like amount (40 g) plant-based protein when compared with animal-based protein on muscle protein synthesis rates in vivo in humans.
o To test the linearity of the LSCI device (Perimed AB, Järfälla, Sweden) and LDI device (Moor Instruments, Devon, UK) in a wide range of blood flux valueso To compare arbitrary units of two different kinds of laser-based devices and to create a…
Objective: The primary objective of this study is to evaluate the pharmacokinetics of midazolam in elderly patients (>70 years) admitted to the ICU.
The objective of this validation study is to determine whether the wearable sensors: HealthPatch, SensiumVitals and the bed-based contact-less EarlySense system are able to detect heart rate and respiratory rate in a clinical setting, with…
The objective of this pilot study is to test the accuracy of the fall-prevention module of the BRAVO-EagleEye. This is done by comparing the alerts generated by the system with the observations of the nurses of the particular ward.
Does the test influence a couples decision to refrain from further treatment.
The aim of our study is to validate the ALPHA-NL. This is important for midwives/obstetricians, and in the end clients, to be able to work evidence-based. Research questions are:- What is the reliability of the ALPHA-NL?- What is the concurrent…
Study BP29541 is a first in-human, open-label, multicenter, dose-escalation Phase I clinical study of single-agent RO6958688. The study will be conducted in two parts. Part I of the study is single ascending dose in single patient cohorts to…
Primary objective: Estimate the MTD and/or RDE of LDK378 as a single agent when administered orally to pediatric patients with ALK-activated tumors in the fasted and in fed stateSecondary objectives: Objective 1: Characterize the safety and…
We want to explore whether disturbances in the oral and gut microbiome can be identified in patients with a high risk of recurrence (determined by a DASH score greater than 1) compared to the oral and gut microbiome of patients with a low risk of…
The primary objective is to investigate the effects of dopamine receptor stimulation on neural and behavioural measures of perception and consciousness. The secondary objective is to establish the relation between the effects of dopamine stimulation…
Managing victimization risks attached to societal participation by people with severe mental illness
The main objective of the study is to gain insight in the effectiveness of the Victoria modules, in terms of acknowledgement for these experiences and risk awareness. These experiences and insights can be used to take acceptable risks in…
Primary Objective: To prove the hypothesis that Intradiscal Methylene blue is capable of longer pain reduction and better global perceived effect in patients suffering from chronic axial low back pain from discogenic origin then a placebo treatment…
To assess (i) the effect of partial neuromuscular blockade (NMB; TOF ratio 0.7) induced by low-dose rocuronium on the ventilatory response to isocapnic hypoxia and (ii) the effect of the reversal by sugammadex, neostigmine or placebo in healthy…
The primary objectives of this study are:* To describe the safety and tolerability of cergutuzumab amunaleukin in combination with atezolizumab* To determine the MTD, if achieved, of cergutuzumab amunaleukin in combination with atezolizumab* To…