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Anticoagulants for Living Fetuses in women with recurrent miscarriage and inherited thrombophilia; ALIFE2 study

To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.

Intrauterine resuscitation during term labor by maternal hyper oxygenation: a pilot study.

To investigate the effect of maternal hyperoxygenation with 100% in the second stage of labor and in the presence of abnormal fetal heart rate (FHR) patterns on fetal condition, instrumental delivery rate and free radical production. In case a…

Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial

First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…

A randomized, double-blind, placebo-controlled, pilot trial of probiotics in pregnant women with symptoms of anxiety and depression.

The primary objective is to assess feasibility of a food supplement (multispecies probiotic) placebo-controlled, randomised controlled, double blind intervention in pregnant women in their late second/third trimester of pregnancy, to reduce symptoms…

Will a cervical pessary prolong pregnancy in women who have been discharged after an episode of threatened preterm labor: a multicenter randomised clinical trial

The APOSTEL-VI study will assess whether a cervical pessary prolongs pregnancy in women who have been admitted for threatened preterm labor with a positive fibronectin test, but remained undelivered. Furthermore we will study whether a cervical…

Prospective randomized trial to evaluate and to compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.

1. To evaluate and compare the impact of hysteroscopic Essure® intratubal device placement and laparoscopic salpingectomy on IVF-ET outcomes of patients with hydrosalpinx.2. It is still uncertain whether laparoscopic salpingectomy for hydrosalpinx…

Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention - A European multicentre, randomised trial: Vitamin D limb.

The overall aim of the DALI study is to identify the best available measures to prevent GDM in an ongoing pregnancy, to provide a cost-benefit calculation of GDM prevention for health care systems, and to establish a pan-European cohort of mother-…

The EPPI Trial - Enoxaparin for the Prevention of Preeclampsia and Intrauterine growth restriction - a open-label randomised controlled trial

Primary objectives:To determine the difference in effect of prophylactic daily LMWH injections with standard high risk antenatal care compared to standard high risk antenatal care only for the prevention of preeclampsia and IUGR and to assess the…

Induction of Labour with a Foley catheter or Misoprostol at Term

To assess in term pregnant women with an unfavourable cervix (Bishop score < 6, Appendix1) the effectiveness of induction of labour with a transcervical Foley catheter as compared to induction with misoprostol.

A phase IIIB, multicentre, multinational, randomized, open-label trial to compare the efficacy and safety of ovarian stimulation with GONAL-f day 1 to day 5 followed by Pergoveris starting day 6 to Pergoveris starting day 1 in women between 36 and 40 years of age undergoing assisted reproductive technique (ART)

The overall objective of this trial is to generate data on the ovarian stimulation profile obtained when Pergoveris® is started either on stimulation day 1 or stimulation day 6 in ART patients between 36 and 40 years of age (both inclusive). A…

ASB treat study: Preventing preterm birth with nitrofurantoin: Costs and effects of screening and treating healthy women for asymptomatic bacteriuria.

To evaluate whether nitrofurantoin treatment for women with asymptomatic bacteriuria is effective in reducing the risk of preterm delivery and/or pyelonephritis. In addition, assessing whether it is cost-effective to do so.

Assessment of Perinatal Outcome by uSe of Tocolysis in Early Labour (APOSTEL IV); Nifedipine versus placebo in the treatment of preterm premature rupture of membranes

To assess whether in women with early PPROM tocolytics improve perinatal outcome.

Preventing preterm birth: Costs and effects of screening of healthy women with a singleton pregnancy for a short cervical length.

To evaluate whether progesterone treatment for women with a short cervical length is effective in reducing the risk of preterm delivery. In addition to assess whether it is cost-effective to do so.

Does antenatal allopurinol during perinatal asphyxia reduce post-hypoxic-ischemic reperfusion damage in the newborn? A double blind randomised placebo controlled multicenter trial.

In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.

Paracetamol intravenously in neonates with a gestational age of less than 32 weeks

Primary objective: to study the pharmacokinetics and pharmacodynamics of paracetamol intravenously in preterm infants with a gestational age of less than 32 weeks:Secondary objective(s): to study the safety and dose-effect relationship of…

Removal versus Retention of Cerclage in Preterm Premature Rupture of Membranes.

The objective of this study is to determine whether retention of cerclage after PPROM improves latency (without a significant increase in chorioamnionitis) and lessens neonatal morbidity.

Misoprostol in the management of retained placenta, a safe alternative for manual removal? A randomised controlled trial

To assess the effectiveness of misoprostol in the management of retained placenta. Will 800 micrograms of misoprostol orally reduce the need for manual removal under general anaesthesia and prove to be a safe alternative?

A comparison of pethidine/meperidine intramusculary and remifentanil patient-controlled analgesia during labor in Westfriesgasthuis

The following hypotheses will be tested:Hypothese a: Remifentanil PCA gives a better labour satisfaction than pethidine/meperidine i.m.Hypothese b: Remifentanil PCA gives a better pain-relief during labour, than pethidine/meperidine intramuscularly.…

First trimester progesterone therapy to reduce miscarriages in women with a history of unexplained recurrent miscarriages: A randomised, double blind, placebo-controlled, multi-centre trial.

To test the hypothesis that in women with unexplained recurrent miscarriages, progesterone started as soon as possible after a positive pregnancy test ) and continued to 12 weeks of gestation, compared to placebo, increases live births beyond 24…

The use of foley catheter results in less interventions as compared to the use of propess

To objective the most efficacy way to ripening the cervix of pregnant women.