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Early versus late intervention for twin reversed arterial perfusion sequence: an open-label randomized controlled trial
*TRAPIST*: TRAP Intervention STudy

To assess if early intervention (12.0-14.0 weeks) (study group) improves the outcome of TRAP sequence as compared to late intervention (16-18 weeks) (control group).

Anticoagulants for Living Fetuses in women with recurrent miscarriage and inherited thrombophilia; ALIFE2 study

To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.

Maternal and offspring outcomes after treatment of hyperemesis by refeeding

In this prospective study we aim to find out whether an early refeeding strategy in addition to standard care can improve maternal and neonatal outcome and reduce hospital stay.

PreCARA: Preconception Counselling in Active Rheumatoid Artritis and other chronic inflammatory arthritides;
Preconception counselling for women with rheumatoid arthritis (RA) or another chronic inflammatory arthritis and a pregnancy wish, which is evaluated in a prospective observational study monitoring pregnancy, delivery, postpartum period of the mother, and (growth) parameters of the child.

In the present study we will evaluate the standardized care protocol developed in our outpatient clinic, intended to guide counselling for medication use prior to pregnancy. This protocol guides treatment decisions based on disease activity,…

A MULTICENTER, POSTMARKETING STUDY TO EVALUATE
THE CONCENTRATION OF CERTOLIZUMAB PEGOL IN THE
BREAST MILK OF MOTHERS RECEIVING TREATMENT WITH
CIMZIA® (CERTOLIZUMAB PEGOL)
PHASE 1B (CLINICAL PHARMACOLOGY)

The primary objectives of this study are to assess whether there is transfer of CZP into breastmilk of lactating mothers who are receiving an established dosing regimen of CZP by evaluatingthe concentration of CZP in mature breast milk, and to…

Pilot study of DEHP and BPA exposure during and after delivery, in mother and child

We seek to elucidate the perinatal exposures to DEHP and BPA with the intention of providing evidence for policy makers and manufacturers. It is our hope that less toxic products will be used in health care and in the general population in the…

INDEX:Costs and effects of induction of labour versus expectant management in women with impending post-term pregnancies: the 41 week-42 week dilemma

First ObjectiveIn this study we compare a policy of labour induction at 41 weeks with a policy of expectant management until 42 weeks, with an outpatient check for CTG monitoring and ultrasound measurement in the 42nd week, with respect to the…

Is antenatal prednisone exposure associated with chronically elevated cortisol levels in children?

The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…

Stop or Go?
Tapering antidepressants in pregnancy: A pragmatic multicenter RCT to investigate risk and benefits for mother and child.

The aim of this study is to investigate the effect of guided tapering in early pregnancy as compared to continuation of SSRIs during pregnancy. We will study effects on both mother and child with a pragmatic approach.

Intrauterine resuscitation during term labor by maternal hyper oxygenation: a pilot study.

To investigate the effect of maternal hyperoxygenation with 100% in the second stage of labor and in the presence of abnormal fetal heart rate (FHR) patterns on fetal condition, instrumental delivery rate and free radical production. In case a…

Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial

First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…

Bright up! A randomized, double-blind, placebo-controlled study of light therapy for depression during pregnancy.

To investigate whether bright light therapy is an effective treatment for depression during pregnancy compared with low-intensity placebo light therapy (proof-of-principle) and to investigate the late effects of bright light therapy versus placebo…

MULTICENTRE RANDOMISED CONTROLLED TRIAL
OF MINIMALLY-INVASIVE SURFACTANT THERAPY IN
PRETERM INFANTS 25-28 WEEKS GESTATION
ON CONTINUOUS POSITIVE AIRWAY PRESSURE

To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).

Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: a pilot study

Th**is study will compare sequential mifepristone and misoprostol (*M&M*) treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.

Will a cervical pessary prolong pregnancy in women who have been discharged after an episode of threatened preterm labor: a multicenter randomised clinical trial

The APOSTEL-VI study will assess whether a cervical pessary prolongs pregnancy in women who have been admitted for threatened preterm labor with a positive fibronectin test, but remained undelivered. Furthermore we will study whether a cervical…

Managing Thrombocyte transfusions in a Special Subgroup: NEonates

To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.

Safeguarding the brain of our smallest children ;* an investigator-initiated randomised, blinded, multinational, phase II
feasibility clinical trial on near-infrared spectroscopy monitoring
combined with defined treatment guidelines versus
standard monitoring and treatment as usual in premature infants

The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…

The hysteroscopic morcellator versus the bipolar resectoscope for removal of residual placental tissue: a randomized controlled trial.

To compare the HM to bipolar resectoscopy for removal of residual placental tissue in terms of efficiency and complications.

Nifedipine versus Atosiban in the treatment of threatened preterm labour:
APOSTEL III

To compare the effectiveness of the tocolytic agents Nifedipine (a calcium channel blocking agent) versus Atosiban (an oxytocin receptor antagonist) in the improvement of neonatal outcome in women with threatened preterm labour (25-34 weeks…

Factors that influence women*s utilization of prenatal screening for Down*s syndrome. Optimizing decision making and refining current and future screening policies by studying differences in uptake rates, between three European countries*

The striking difference in uptake of Down*s Syndrome screening between countries that otherwise show close resemblance, particularly regarding healthcare policy, social and cultural factors (including non-directiveness of counselling, autonomous and…