160 results
The primary objective is to determine if there is an association between the presence of vertebral and/or rib anomalies and congenital malformations, aneuploidy or adverse fetal outcome, in order to assess whether detailed evaluation of the…
The main objective of this study is to analyse the effect of preeclampsia on levels of memory T cell subsets in peripheral blood.
The objective of the study is to determine the protein profile of cerebrospinal fluid of non-pregnant women using mass-spectrometry.This study is a follow-up project on the previously performed study (LEPRA, CSF and pre-eclampsia, MEC 2007-087). In…
Developing a risk score based on established risk factors and personality traits, to predict possible postnatal anxiety/depression with or without problems in bonding between mother and child at the first consult at the midwives practice or…
The next questions will be addressed in the present study: 1. Do moderately preterm infants differ in development and attention and concentration capacities from a term and very preterm infants during the first years of life? 2. Do attention and…
The purpose of the sub-study is to do research into markers which will hopefully assist to diagnose the condition Peripartum Cardiomyopathy as early as possible. The blood donated for research will also assist in the assessment of women having a…
1. To investigate the influence of different immunosuppressive drugs on the immune response of placental derived mononuclear cells, peripheral blood derived mononuclear cells, and cord blood derived mononuclear cells.2. To investigate the neonatal…
Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?
• To assess the added predictive value to known clinical predictors of a questionnaire that generates bleeding scores during pregnancy with regards to predicting (major) obstetric haemorrhage. • To describe the associations of haemostasis and…
We hypothezise that hypertension in pregnancy, spontaneous preterm birth and cardiovascular disease in later life share pathophysiological features of endothelial dysfunction. We will investigate this on two levels including local on tissue level…
In view of this lack of evidence and strong practice variation we propose a randomized clinical trial in overweight and obese subfertile women, in which we compare the costs and effects of a six months structured lifestyle program, aimed at weight…
We hypothesize that formerly pre-eclamptic women have persistently increased angiotensin II sensitivity, sodium sensitivity, insulin resistance and sympathetic nerve activity together initially leading to susceptibility for early renal disease and…
The principal aim of this study is to elucidate the role of the glycocalyx in the pathogenesis of pre-eclampsia by assessing: - Whether the glycocalyx is affected in pre-eclampsia and is related to its severity.- Whether glycocalyx perturbation is…
To test The Selection Failure hypothesis by assessing A) the degree of embryo invasiveness and decidual acceptance (the quality of decidualization, endometrium-embryo communication and endometrial stromal cell (ESC) migration) and B) the angiogeneic…
1. To obtain early diagnostic and prognostic markers for preterm premature rupture of membranes and premature labour, based on ultrasound examinations of mother, placenta and fetus and markers present in blood and urine of mother at 11-14 weeks and…
The main goal of this study is to examine the clinical applicability of the Monica AN24*, for the use of this device in the LUMC for prolonged CTG-registrations in high risk pregnancies and particularly in monitoring fetal cardiac arrhythmias. The…
The objective of this study is to determine whether placental pathology is associated with early neonatal morbidity and the neurological development in late preterm infants.We hypothesise that more developmental pathology of the placenta will be…
Immunodetection of Thyrothrophin (TSH) receptor in myometrium tissue.Furtermore the aim is to test myometrium tissue in vitro for it's relaxation and contractility and it's conductance of electropotentials.
The objective of this study is to better understand the forces and tongue movements that a baby uses while drinking at the breast and to what extent they contribute to effective feeding.
To collect maternal blood during the 2nd half of pregnany, in combination with clinical data and data on pregnancy outcome.