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Obstetric anal sphincter injury, a follow-up study on the long term outcome.

Aim of the study is to get informed on the outcome of women treated in the MUMC for obstetric anal sphincter injury between 2005 and 2012. The controlgroup is matched for maternal age at delivery, parity, mode of delivery and child weigth.

Standardized episiotomy with a new device: BasIQ

To assess if the *BasIQ* makes a standardized incision of 4 cm.

Indicated amniotomy in the latent phase of labour

To judge if there is a difference between referral rates during labour when an amniotomy is performed in the latent phase of labour, compared to an expectant policy.

Uterine contractions monitoring using the electrohysterogram.

To study the validity of the AN24 monitor for uEMG monitoring of uterine contractions compared to intra-uterine pressure monitoring during labour.

The intra uterine pressure catheter, the best way to messure uterine contractions?
A comparison of the intra uterine pressure catheter and the abdominal uterine pressure measurement during labor

The objective of this study is to find out is the way contractions are maesurent during labor are of any influence on the lenght and the way women deliver. It also looks if there is any influence on neonatal outcome.

The use of foley catheter results in less interventions as compared to the use of propess

To objective the most efficacy way to ripening the cervix of pregnant women.

Elastographical and Ultrasonic Properties of the Liver and Hepatic Circulation during severe preeclampsia/HELLP Syndrome

The aim of this study is to test the hypothesis that severe pre-eclampsia/HELLP syndrome in comparison to patients without severe preeclampsia/HELLP are accompanied by changes in hepatic circulation and themselves cause changes in elastographic…

Blood Volume Measurement using HES injection, and Noninvasive Cardiac Output Measurement to Assess Hemodynamic Responses During Elective Cesarean Section.

Primary objective: To identify those groups of pregnant patients, planned to undergo cesarean delivery, who are at risk to develop severe hypotension (defined as a decrease of at least15% from the baseline tension) based on their preoperative volume…

Hemodynamic Adaptation in the Peripartum Period using Impedance cardiography (HAPPI).

The main aim of this study is to improve knowledge on the hemodynamic burden of labour in women with cardiac disease and women without cardiac disease, by examining CO trajectory through the full course of labour. Therefore, we specified the…

Benefits of Assessment of the Lower uterine segment in predicting a successful trial of labour in women with a history of one previous caesarean section

To develop a prediction model for women with one previous caesarean section by combining assessment of the lower uterine segment with an extensive antepartum history taking and postpartum follow up.

Pharmacokinetics, safety and efficacy of methylphenidate during pregnancy in women with Attention-Deficit (Hyperactivity) Disorder

Primary objective is assessment of the pharmacokinetic profile of MPD in pregnancy. Secondary objectives are the safety and efficacy of any use of MPD during pregnancy.

BasIQ-4® a new approach towards performing episiotomy

Primary objectives: The main objective of this Post Market Clinical Follow-Up (PMCF) study is to further evaluate and monitor the safety and performance of the *BasIQ-4®* in a population of women delivering in general hospitals in The Netherlands…

Controlled hypotensive versus massive fluid resuscitation strategy: influence on blood loss and hemostatic parameters in obstetric hemorrhage

In women with early, mild PPH (blood loss 500-750ml) we would like to establish whether restrictive resuscitation strategy reduces the progression to severe PPH (blood loss > 1000 ml) compared to care as usual