18 results
In this study the test characteristics of the early structural ultrasound examination (SUE) (at 13-14 weeks) will be evaluated and compared the those of the standard SUE/AUE at 20 weeks. Also, the amount of (in-)conclusive examinations and the…
To establish benchmark values in healthy control fetuses, to compare these with our cohort of fetuses with severe CHD.
1. To evaluate the clinical usefulness of STIC with post-process rendering capability. Our goal is to investigate whether STIC gives more accurate information about a suspected cardiac anomaly, compared to conventional 2D ultracardiography.2. To…
Developing a non-invasive test for detection of trisomy 21,13 orr 18 in the unborn fetusDeveloping a standardised protocol, inclusive quality criteria for the use of massive parallel sequencing of celfree fetal DNA in maternal plasmaOptimalising…
We will investigate the feasibility of using STIC technology to evaluate the fetal cardiac anatomy in different stages of gestation. Further we will investigate the fetal cardiac function using STIC technology.
The aim of this study is to investigate whether it is possible to improve genetic diagnostic testing in case of fetal abnormalities and a normal karyotype. We are interested in the relevance of the additional genetic testing.We wish to study the…
Both RCTs and long-term follow-up studies are required to establish optimal fetal management and provide clinicians a better understanding of the impact of these early interventions on child development in order to improve the quality of antenatal…
The focus of this study is to get more insight in the pathophysiology of IUGR. The main goal is to investigate the applicability of STIC in determining fetal cardiac function in IUGR.
Nemo Healthcare B.V. recently developed a new technique for monitoring the unborn baby. This technique is already widely used in unborn babies over 37 weeks of gestational age. The purpose of this study is to examine if that new technique is also…
To investigate the effect of increasing gestation on fetal myocardial deformation values.To explore fetal heart rate variability and fetal ECG waveform parameters in both healthy and growth-restricted fetuses, measured with non-invasive fetal…
This study aims to validate NI-fECG monitoring as an accurate and reliable monitoring technique for FHR, MHR and UA surveillance during labour. The aim of this validation is to work towards clinical implementation of NI-fECG monitoring.
This pilot study aims to explore the possible technical and practical problems that may be encountered when intrapartum NI-fECG monitoring is performed (PF2 study). The results of this pilot study will be the basis for a larger validation study…
Primary Objective: To assess the hemodynamical effects of administration of AS in FGR fetuses and to compare these effects with those that occur in appropriate for gestational age (AGA) fetuses. Secondary Objective(s): To investigate the effect of…
Does, in late preterm fetuses identified as small-for-gestational-age (SGA), timing of delivery based on abnormal umbilicocerebral ratio (UCR) improve neurodevelopmental outcome?
1. Validation of the currently used fetal RHD genotyping platform according to IVDR 2017/746 guidelines;2. Validation of an adapted fetal RHD genotyping platform (different liquid handling system and DNA isolation kit) according to IVDR 2017/746…
This proposal aims to evaluate the use of STE as a diagnostic tool for early diagnosis of impaired fetal growth in twins. The results from this proposal will be beneficial from a public health perspective, as it will lead to accurate and early…
Assessment of whether fetal RHD genotyping can be performed earlier in pregnancy, i.e. around GW11 instead of the moment around GW27.
Determine the number of hypoglycemic events (fasting and postprandial) during post-bariatric pregnancies compared to non-bariatric pregnancies (with obese and healthy BMI) using continuous glucose monitoring and its effects on fetal growth.