Search for a trial

Pregnancy Outcomes after Maternity Intervention for Stressful EmotionS (PROMISES)

To assess the effects of Cognitive Behavioral Therapy (CBT) in pregnant women with symptoms of anxiety or depression on the child*s behavioral/emotional problems. In addition, we aim to study its effects on the child*s development, maternal mental…

High disease activity and prednisone use during pregnancy; lifelong consequences for children of mothers with rheumatoid arthritis?

The aim of the current study is to get insight into the in potential lifelong consequences of active disease and or prednisone use during pregnancy on the children of women with rheumatoid arthritis. As readout it uses indicators (risk factors) for…

Does antenatal allopurinol during perinatal asphyxia reduce post-hypoxic-ischemic reperfusion damage in the newborn? A double blind randomised placebo controlled multicenter trial.

In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.

Immunisation of pregnant women with acellular Bordetella pertussis vaccine.

1) To test the feasibility of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in newborn babies.2) To test the safety of vaccinating pregnant women against B. pertussis in preventing B. pertussis infection in…

The Haemodynamic Significant Patent Ductus Arteriosus (PDA) in preterm infants: significance of different echocardiographic markers, clinical signs, Near Infrared Spectroscopy (NIRS) and B-type Natriuretic Peptide (BNP).

In this study we want to determine the most adequate parameters (clinical, echocardiographic, Near Infrared Spectroscopy (NIRS) and B-type Natriuretic Peptide (BNP)) to diagnose a hemodynamic significant PDA. A second objective is to gather normal…

Optical spectroscopy for monitoring bilirubin and hemoglobin levels in neonates

In this study, we will investigate the use of optical spectroscopy in determining neonatal bilirubin and hemoglobin blood levels. The outcome and accuracy of the optical spectroscopy measurements will be compared to the outcome of laboratory blood…

Non-invasive diagnosis of fetal Down syndrome using fetal DNA or RNA present in the maternal blood

The final aim of the study is the implementation of a test for the detection of fetal Down syndrome via noninvasive procedures, with the same characteristics as the tests that are currently being used (sensitivity and specificity). This test can…

Study on Hypothermia-Induced Variations in pharmacokinetic Effect Relationships

Study (population) pharmacokinetics of midazolam, morphine, phenobarbital and lidocaïne during therapeutic hypothermia for adequate dose adjustments.

The Microcirculatory Profile in Necrotizing Enterocolitis

To establish microcirculatory profiles using non-invasive diagnostic imaging in NEC.

Follow-up GEEF-study: Behavioral development, school performance, neurocognitive functioning and brain development of very premature (<32 weeks) and/or very low birth weight (<1500 grams) children at school-age, with or without glutamine suppletion after birth

The main objective of the study is to provide insight in the developmental problems of very premature and/or VLBW children compared to their term born peers, and to investigate the possible beneficial longitudinal effects of the GEEF intervention on…