100 results
The primary objective of this study is to demonstrate the effectiveness of the DS compared to the SoC group. The secondary objectives:(#1) is to describe the asthma management actions by HCPs for all patients in both groups. (#2) is to evaluate…
This study has been transitioned to CTIS with ID 2024-518803-23-00 check the CTIS register for the current data. To evaluate the safety and efficacy of DOAC versus VKA in CTEPH/CTED patients receiving BPA, based on the composite endpoint of…
This study has been transitioned to CTIS with ID 2023-507889-89-00 check the CTIS register for the current data. REMAP-CAP: The goal of the study is to investigate the best treatment regime for pneumonia patients. For non-pandemic pneumonia (…
Primary objective: to investigate MPA exposure in a variety of autoimmune diseases in stable treated patients. Secondary objective: to develop predictive exposure models and evaluate the influence of population covariables on pharmacokinetics .The…
Main objective:To assess the effects of selexipag on right ventricular (RV) function in participants with PAH.Secondary objectives:- To further assess the effects of selexipag on RV function using MRI.- To assess the effects of selexipag on disease…
The objective is to investigate if there is a flow-dependent effect of HFNC on ventilation during an EBUS procedure under procedural sedation in patients with COPD gold class 3-4.
Main Phase:To demonstrate the superiority of medium-dose BDP/FF/GB pMDI compared to high-dose BDP/FF pMDI in terms of the proportion of subjects exhibiting on average NPAL over 26 weeks of treatment in the study sub-population with PAL at screening…
As part of your treatment, you will receive DUPIXENT. We would like to learn what the experiences of patients are with this medical product and if you notice any changes. The aim of the study is to better understand the characteristics of patients…
This study aims to evaluate the PK profile and IIV of drug exposure in plasma in children (aged 6-17 years) receiving (elexacaftor-)tezacaftor-ivacaftor. Secondary objectives are to evaluate the relationship between covariates and PK parameters that…
To determine the effect of hypertonic saline inhalation and best supportive care versus best supportive care alone on clinical efficacy measures in patients with nodular-bronchiectatic M. avium complex pulmonary disease, as measured by changes in…
Primary objective: to identify predicting phenotypical and endotypical biomarkers for the response to dupilumab in adult patients with CRSwNP, by comparing the type 2 inflammation in the peripheral blood and nasal polyp tissue at baseline and after…
This study aims to investigate the effectiveness of a smart inhaler based asthma self-management programme on medication adherence in adults with partially controlled or uncontrolled asthma. Secondary objectives are 1) to evaluate the effect of the…
a. To determine what proportion of COPD patients demonstrate EFL during NIV useb. To determine the range of EPAP necessary to overcome EFLc. To determine longitudinal change of EFL with time and interaction with exacerbationd. To describe the…
This study has been transitioned to CTIS with ID 2023-508300-37-00 check the CTIS register for the current data. To investigate the effectiveness of triple therapy (ICS/ long-acting beta 2 agonist (LABA)/long-acting muscarine antagonist (LAMA)) on…
This study is designed to assess the proportion of asthma and COPD subjects making critical and non-critical errors in using NEXThaler compared with Turbuhaler after 4 weeks of clinical use. This will give insight in the importance of triple…
Primary Objective To demonstrate that ICS can be safely withdrawn in T2-low asthma patients with obesity in secondary care (i.e. without loss of asthma control).Secondary Objectives1. To determine predictive factors for successful ICS withdrawal.2.…
This research proposal aims to assess the anti-inflammatory effects after 6 weeks treatment with tiotropium compared to placebo in patients with stable COPD.
To assess whether ADRB2 genotype-guided asthma treatment in children with persistend athma symptoms despite ICS treatment leads to better asthma control compared to non-genotype-guided asthma treatment.
To investigate the effect the effect of a 3-months treatment with Reslizumab on small airways function in patients with severe eosinophilic asthma, and to relate the changes in small airway function to changes in asthma symptoms and quality of life.
The aim of this study is to see if the Snoozeal device is as effective as the previous methods and if it can reduce snoring and improve sleep quality.