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Assessment of inflammatory response of bronchial cells to gastric juice from hospitalized infants on and off proton pump inhibitor (PPI) therapy, PICU admitted children and long term users (0-18 years) of PPIs and controls off PPI

Quantify inflammatory response (through IL-8 production) of bronchial (both commercial available cells and cultivated brushed infant cells) when exposing these to gastric juice from: hospitalized Infants, before and during PPI treatment and age…

A randomised, double-blind, placebo- and active-controlled parallel group study to assess the efficacy of 12 weeks of once daily treatment of two doses of orally inhaled tiotropium + olodaterol fixed dose combination (delivered by the Respimat inhaler) in patients with Chronic Obstructive Pulmonary Disease (COPD)

The objective of the proposed study (1237.25) is to evaluate maximal treatment effect in FEV1 and SGRQ after 12-weeks treatment with two different doses of tiotropium + olodaterol FDC (5*g/ 5*g and 5*g/ 2.5*g) by comparison with placebo in patients…

The *Spacemaker*: evaluating a new surgical lung spatula for an optimal fit

In our current study we would like to evaluate a newly developed surgical platform for minimal invasive cardiothoracic surgery: the soft tissue expander. Main objective of the study is to determine the feasibility of creating a trans tissue expander…

The effect of High Pressure level determined by Electrical Impedance Tomography on hemodynamics during Airway Pressure Release Ventilation (APRV) in patients with severe ARDS:
a pilot-study

Primary objectiveTo detect the difference in mean arterial blood pressure between conventional APRV settings and APRV settings based on EIT measurements, in patients with ARDS.Secondary objectivesImproved dorsal ventilation distribution on EIT…

Investigation of the applicability of dry powder inhalation in children with cystic fibrosis

The main objective is to determine whether children with CF are able to achieve an inhalation manoeuvre as required for aerosol generation and transport into the peripheral airways with the test inhaler. The secondary objectives are to determine…

Multicenter randomized 2x2 cross-over study for patient satisfaction and function of the ProTrach DualCare

In this research we want to determine whether patients prefer the ProTrach DualCare over other speaking valves, if it improves quality of life, compliance with HME use and lung function.

Combined PSGand HRM-MII measurement to assess the relation between gastroesophageal reflux and apnea in infants

Determine the existence of a relation between GER and apnea and their underlying mechanisms, in infants *37 weeks * 12 months.

Analysis of the clinical effects of head positional therapy with the Sleep Position Trainer Wave in the treatment of Positional Obstructive Sleep Apnea

Evaluation of the effect of positional therapy with the SPT Wave on sleep apnea severity, i.e. re-duction of the apnea-hypopnea index (AHI).

A RANDOMISED, DOUBLE-BLIND, DOUBLE-DUMMY, ACTIVE-CONTROLLED STUDY EVALUATING THE EFFICACY, SAFETY AND TOLERABILITY OF TWICE-DAILY ACLIDINIUM BROMIDE /FORMOTEROL FUMARATE COMPARED WITH TWICE-DAILY SALMETEROL/FLUTICASONE PROPIONATE FOR 24-WEEKS TREATMENT IN SYMPTOMATIC PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Section 7 of the protocol:7. TRIAL OBJECTIVES AND PURPOSE* To assess the long term bronchodilator efficacy of Aclidinium bromide/Formoterol fumarate, administered twice a day, compared to Salmeterol/Fluticasone propionate (SeretideTM AccuhalerTM) in…

Low dose dexamethasone in newly diagnosed sarcoidosis

The main objective of this intervention study is to assess the effects of low-dose dexamethasone therapy on the quality of life of newly diagnosed sarcoidosis patientsThe secondary objectives are to assess the effects of low-dose dexamethasone…

AMB115811: A randomised, multicentre, double-blind, placebo-controlled study of ambrisentan in subjects with inoperable chronic thromboembolic pulmonary hypertension (CTEPH)

Primary: to assess the efficacy of ambrisentan 5mg after treatment period of 16 weeks, in subjects with inoperable CTEPH. Secondary: safety and tolerability.

Multicenter 3-arm trial to evaluate the efficacy and safety of Pasireotide LAR or Everolimus alone or in combination in patients with well differentiated neuroendocrine carcinoma of the lung and thymus -LUNA Trial

To evaluate the efficacy of pasireotide LAR and everolimus alone or in combination in progressive patients with a well differentiated neuroendocrine tumor of the lung or thymus.

Effect of pre-surgical pulmonary rehabilitation on outcomes of bariatric surgery in morbidly obese patients with asthma

To determine whether pulmonary rehabilitation prior to bariatric surgery leads to improved and sustained asthma control (ACQ) as compared to bariatric surgery alone in patients with morbid obesity and not optimally controlled asthma.Secondary aims…

A Phase 2, Randomized, Double-blind, Placebo-controlled, Efficacy and Safety Study of
Inhaled JNJ-49095397 (RV568) in Subjects With Moderate to Severe Chronic Obstructive
Pulmonary Disease

Primary ObjectiveThe primary objective is to assess the efficacy (as measured by change from baseline in prebronchodilator [preBD] percent predicted forced expiratory volume in one second [FEV1]) of JNJ-49095397 compared with placebo in subjects…

An explorarory, 12 week, randomised, partially double-blinded, placebo-controlled parallel group trial to explore the effects of once daily treatments of orally inhaled tiotropium + olodaterol fixed dose combination or tiotropium (both delivered by Respimat® inhaler), supervised exercise training and behavior modification on exercise capacity and physical activity in patients with Chronic Obstructive Pulmonary Disease (COPD)

The primary objective is to confirm that bronchodilator monotherapy (tiotropium) plus behavioural modification, bronchodilator combination therapy (tiotropium + olodaterol FDC) plus behavioural modification, and bronchodilator combination therapy (…

Control of breathing in systemic sclerosis

-To assess the central chemosensitivity by an carbon dioxide rebreathing test-To assess mouth occlusion pressures during the carbon dioxide rebreathing test-To study the relation between these results and the results obtained with the MRI and…

A multicenter, open-label, randomized phase II study to evaluate the efficacy of AUY922 vs pemetrexed or docetaxel in NSCLC patients with EGFR mutations who have progressed on prior EGFR TKI treatment (CAUY922A2207)

Primary: Progression Free Survival (PFS) in patients treated with AUY922 versus pemetrexed or docetaxel.Secondary: Overall response rate, disease control rate, overall survival, safety and tolerability, PK.

The power and the flow: raising the bars in the treatment of pulmonary arterial hypertension

The primary goal of the study is to assess whether a goal oriented strategy to preserve/improve right ventricular function by application of upfront combination therapy will improve clinical outcome. Study questions:1. Will a goal oriented strategy…

Nasal Potential Difference in suspected CF patients with 5T polymorphism * Comparison between patients from Israel and Netherlands

Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.

A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating CNTO 3157 in Healthy Normal and Asthmatic Subjects Inoculated with Human Rhinovirus Type 16

The primary objective of Part 2 of this study is to determine the efficacy of pretreatment with CNTO 3157 compared with placebo in attenuating the respiratory manifestations of inoculation with HRV-16 in adult subjects with mild to moderate asthma.…