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A placebo-controlled, randomized, safety and efficacy study of BOTOX® (Bolulinum Toxin Type A) Purified Neurotoxin Complex in patients with neurogenic detrusor overactivity and neurological respiratory impairment.

To evaluate the safety and efficacy of 2 dose levels of BOTOX® (200 U or 300 U) compared to placebo injected into the detrusor for the treatment of urinary incontinence caused by neurogenic detrusor overactivity in patients who have not been…

Temporary limited peak pressure increase following endotracheal suctioning in ventilated patients.

the aim of the study is to assess whether short lived limited increases in airway pressure are sufficient to combat ET suction induced hypoxemia

Randomized phase II study of amrubicin as single agent or in combination with cisplatin versus etoposide-cisplatin as first-line treatment in patients with extensive stage SCLC (ES).

Investigate the activity and safety of amrubicin alone versus amrubicin incombination with cisplatin versus standard treatment for extensive disease(ED) small-cell lung cancer in the first line setting.

Vacuum-Assisted Closure versus Closed Drainage using Redon Catheters for the Treatment of Mediastinitis: a Prospective Study

.Currently, vacuum-assisted drainage and closed drainage using redon catheters are widely accepted methods for the treatment of mediastinitis. However, it is unknown which technique is considered to be the most effective. We hypothesize that closed…

A Prospective, Randomized, Placebo-Controlled Multicenter Study to Evaluate the Performance of the IBV Valve System for the Treatment of Severe Emphysema

The objective of this randomized, blinded, multicenter, controlled study is to compare the performance of the IBV* Valve System (treatment group) to a control group receiving a sham bronchoscopy procedure without valve placement

Efficacy of Inhaled RhDNase in Mechanically Ventilated Pediatric Patients with an Atelectasis

To evaluate the efficacy of inhaled rhDNase in addition to conventional treatment in children with an atelectasis during mechanical ventilation.

*A prospective, randomised trial in pneumothorax therapy: manual aspiration versus conventional chest tube drainage.*

To evaluate the efficacy of manual aspiration in comparison to conventional chest tube drainage in pneumothorax therapy:1.whether the lung will expand by means of clinical and radiological findings.2.whether manual aspiration will shorten hospital…

Lobectomy for the treatment of non-small cell lung cancer (NSCLC):
video-assisted minithoracotomy (VAMT) versus muscle-sparing thoracotomy (MST)

see K1

Prospective study on cost-effectiveness of the Provox®2 and the Groningen Ultra Low Resistance tracheoesophageal shunt prostheses in voice rehabilitation of post-laryngectomy patients.

The objective of the study is a prospective study to evaluate which type of TE shunt prosthesis is the most cost-effective.

A 16-Week International, Multicenter, Double-Blind, Randomized, Placebo Controlled Comparison of the Efficacy and Safety of Oral UT-15C Sustained Release Tablets in Combination with an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 Inhibitor in Subjects with Pulmonary Arterial Hypertension

Primary: To assess the effect of UT-15C sustained release (SR) on exercise capacity compared to placebo (as measured by the change in 6-Minute Walk distance from Baseline to Week 16) in subjects with PAH.Secondary: To assess the effect of UT-15C SR…

A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF UK- 432,097 DRY POWDER FOR INHALATION IN ADULTS WITH MODERATE TO SEVERE CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Primary ObjectiveTo evaluate the efficacy and safety/tolerability of UK-432,097 DPI in adults with moderate to severe COPD (GOLD stage II/III).

A single centre, double blind, randomised, parallel group study to explore the efficacy and tolerability of intranasal fluticasone propionate compared with placebo delivered by the OptiNose device in adult subjects with chronic rhinosinusitis.

The aim of this study is to investigate if bidirectional delivery, by delivering more drug to the region of the sinus ostia, improves upon the efficacy of current nasal steroids in chronic rhinosinusitis.to get information about the efficacy, safety…

Bronchiectasis and long term Azithromycin (AZM) Treatment:
a randomised placebo-controlled trial studying disease modifying effects of immunomodulating treatment

Primary objectives1. Does prolonged antibiotic treatment with AZM reduce the number of bacterial exacerbations in patients with bronchiectasis?2. Does treatment with AZM increase lung function parameters (Δ FEV1, Δ FVC )?Secondary objectives1. Is…

A randomized, double-blind study to evaluate the safety and effectiveness of the Exhale Drug-eluting stent in homogeneous emphysema subjects with severe hyperinflation, the "EASE - study".
& Local ammendment: Protocol revision to evaluate the ExhaleUltraNeedle in the EASE study.

Main: To evaluate the safety and effectiveness of the Exhale Drug-Eluting Stent (DES) to improve pulmonary function for homogeneous emphysema subjects with severe hyperinflation, in a prospective, randomized, Sham-controlled, double-blind, multi-…

A Phase 1/2 Study Evaluating the Safety and Efficacy of ABT-751 in Combination with Pemetrexed Versus Pemetrexed Alone in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer

The primary objective of the Phase 2 portion of the study is to assess if the addition of ABT-751 at the RPTD to standard pemetrexed can prolong PFS compared to pemetrexed alone in subjects with advanced or metastatic NSCLC.

A study evaluating the effects of a structured lifestyle intervention on daily physical activity level of COPD patients in the first, second and third echelon.

The aim of the study is to investigate the effects of a structured lifestyle program (in the first, second and third echelon) on the physical activity level of COPD patients

Clinical Outcome of Postoperative Mediastinitis: Sternal Closure Versus Conventional Treatment

The aim of this study is to compare the clinical outcome and survival in patients undergoing sternal closure treatment or conventional treatment for postoperative mediastinitis. The secondary objective is to determine incidence of mediastinitis and…

A study of respiratory waveforms derived using up to three motion monitoring systems in 4D radiotherapy planning and delivery

To compare respiratory waveforms generated using reflective markers located on the upper abdominal wall (the currently used Varian RPM system) with either magnetic sensors, belt sensors or both placed on the chest wall and/or upper abdomen. The…

The effect of nebulised MgSO4 on lung function in stable severe asthma patients with persistent airflow limitation

To test this hypothesis by administering inhaled isotonic magnesium sulphate to patients with stable severe asthma and persistent airflow obstruction (postbronchodilator FEV1 < 75% predicted) and determine the bronchodilating effect by…

Concurrent ONce-daily VErsus twice-daily
RadioTherapy: A 2-arm randomised controlled trial of
concurrent chemo-radiotherapy comparing twice-daily
and once-daily radiotherapy schedules in patients with
limited stage small cell lung cancer (SCLC) and good
performance status.

To compare the primary endpoint (overall survival) between the two arms of the studySecondary endpoints are:Local progression-free survivalMetastases-free survivalCTCAE v3.0 toxicityChemotherapy dose intensityRadiotherapy dose intensity