110 results
The aim of this study is to identify barriers and facilitators for successful implementation of the care pathway, to ultimately inform national scale-up of the pathway.
Primary ObjectiveTo assess the accuracy of inspiratory capacity measurements performed by COPD patients at rest in a unsupervised home setting compared to a supervised setting.Secondary objectives - To assess the accuracy of inspiratory capacity…
The main objective is to investigate the heterogeneity of type 2 asthma by identifying phenotypes by means of cluster analysis. Secondary, the clinical interpretation of these clusters is investigated.
Our primary objective is to determine the prognostic value of parameters for early disease detection of familial pulmonary fibrosis in the study population. All putative parameters for detection of preclinical disease have been shown to be…
The study has the purpose and rationale to establish the antiviral efficacy of ensovibep against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, identify the optimal dose, and demonstrate its clinical value for treating COVID…
In this study we aim to assess: 1.the diagnostic yield of endobronchial biopsy taken during HD videobronchoscopy in a large study population;2. the prevalence, visual pattern and specificity (for the detection of granulomas) of airway abnormalities…
To identify the characteristics on CLE images of the alveolar compartment in mechanically ventilated COVID19 patients with non-resolving acute respiratory failure.
To determine the impact of prior BCG vaccination on the duration of immunogenicity of the BioNTech/Pfizer mRNA COVID*19 vaccine.
• To demonstrate the efficacy of ATR-002 versus placebo in addition to standard of care based on the clinical severity status in adult hospitalized patients with COVID-19• To show that ATR-002 in addition to standard of care shortens the time to…
Clinical Trial Protocol section 2.The main objectives of the trial are to assess the safety and tolerability of two doses of ABNCoV2, formulated with and without the adjuvant MF59, in healthy adult volunteers and to identify the dosage and…
To examine the impact of RSV infection on the diversity of the upper respiratory tract microbiome, measured by the Shannon index.
Primary Objective:To evaluate the efficacy potential, safety and tolerability of intravenously administered ANXV, in ascending doses, and two different dosing regimens, in patients with confirmed moderate to severe COVID-19.Secondary Objectives:To…
The primary objective is to study the agreement between the peak-to-through EAdi-oes signal and the EAdi-tc signal. Secondary objectives include a) to study the sensitivity and specificity of the EAdi-tc signal to detect dyssynchronous breaths using…
Our main aim is to validate the TiMaSCAN as both a diagnostic and monitoring tool in the treatment of pulmonary exacerbations in CF patients.
Aim 1. To study the impact of different sequences of combined influenza and SARS-CoV-2 vaccinations on immunological responses and sideeffects.Aim 2. To understand the immunological mechanisms that mediate the potential interference between…
In this study, the aim is to derive optimal imaging procedures and to assess the technical performance of the Vision Quadra PET/CT system concerning its feasibility to detect indeterminate lung nodules. Furthermore, this study aims to preliminary…
Development of a diagnostic algorithm that will diagnose measles cases and classify (potential) contagiousness of patients following measles infection.
The overall objective of this trial is to evaluate the concept of pharmacological activity of BI 767551 in non-hospitalized patients with mild to moderate COVID-19 symptoms and to identify a potentially efficacious and safe dose regimen from Phase…
To investigate the influence of air temperature and humidity on the occurrence of EILO. A better understanding of the pathophysiologic principles causing EILO could lead to increased sensitivity of CLE testing. New insights in the causes of EILO can…
In this study, we hypothesize that the reference product (SalbR/Ventolin) is more effective than SalbG (Salbutamol Sandoz) atimproving the lungfunction in children with asthma, and that this difference increases alongside the severity of the airway…