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Treatment of Chronic Idiopathic Cough (CIC) and Chronic Cough in patients with Idiopathic Pulmonary Fibrosis (IPF) with PA101.

The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…

A Phase 2b, Randomized, Double-Blind, Placebo-Controlled Multi-Center Study Evaluating Antiviral Effects, Pharmacokinetics, Safety, and Tolerability of GS-5806 in Hematopoietic Cell Transplant (HCT) Recipients with Respiratory Syncytial Virus (RSV) Infection of the Upper Respiratory Tract

The co-primary objectives of this study are as follows:* To evaluate the effect of presatovir (GS-5806) on RSV viral load and development of lower respiratory tract complication (LRTC) in RSV positive autologous or allogeneic HCT recipients with…

Cisplatin or Cetuximab and conventional versus redistributed radiation for advanced head and neck cancer

This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…

Safety and Performance of a Bioabsorbable Fluticasone Propionate-eluting sinus dressing
(SinuBand) in the Postoperative management of Functional Endoscopic Sinus Surgery in patients
with Chronic Rhinosinusitis

This study is designed to evaluate the safety and performance of SinuBand, a bioresorbablefluticasone propionate-eluting sinus dressing in the postoperative management of FESS in patientswith chronic rhinosinusitis. The study will collect both…

Phase 2 clinical feasibility study of a new Speaking Valve with a heat- and moisture exchanger (TW) for tracheotomized patients.

The Purpose of the study is to investigate the clinical feasibility of the TW15 and TW22.

A single centre, double blind, randomised, parallel group study to explore the efficacy and tolerability of intranasal fluticasone propionate compared with placebo delivered by the OptiNose device in adult subjects with chronic rhinosinusitis.

The aim of this study is to investigate if bidirectional delivery, by delivering more drug to the region of the sinus ostia, improves upon the efficacy of current nasal steroids in chronic rhinosinusitis.to get information about the efficacy, safety…

A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER TRIAL TO ASSESS THE ORAL CORTICOSTEROID*SPARING EFFECT OF LEBRIKIZUMAB IN PATIENTS WITH SEVERE CORTICOSTEROID-DEPENDENT ASTHMA.

PRIMARY OBJECTIVES * To evaluate the efficacy of lebrikizumab compared with placebo as measured by theability of patients to achieve lower daily doses of OCS while maintaining control oftheir asthma* To evaluate periostin as a predictive biomarker…

A randomized, double-blind, placebo-controlled, study to determine the added value of vitamin D3 to treatment with subcutaneous immunotherapy (SCIT) in patients with moderate to severe allergic rhinitis/ rhinoconjunctivitis caused by birch pollen

The aim of this clinical phase IIa randomized, double-blind, placebo-controlled study is to investigate tolerability/ safety and clinical and immunological effects of the addition of a subcuteaneous injection of a VD3 analogue in the vicinity of the…