54 results
The co-primary objectives of this study are as follows:* To evaluate the effect of presatovir (GS-5806) on RSV viral load and development of lower respiratory tract complication (LRTC) in RSV positive autologous or allogeneic HCT recipients with…
Primary:To evaluate the efficacy of 100mg mepolizumab compared to placebo.Secondary:The impact on actual nasal surgery. Further efficacy assessment. Quality of life.
To evaluate the effect and cost-utility of positional therapy, comparing the SPT and MRA versus CPAP in patients with moderate positional obstructive sleep apnea.
To compare the effect of two different types of mandibular advancement device (MAD) on polysomnographic (PSG) parameters, to evaluate the compliance and to evaluate the outcome of the different Quality of Life scales, eg general health with the…
The most important questions of this phase III trial is:Can adaptive high dose radiotherapy improve loco-regional control without increase of toxicity?
The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…
The purpose of this pivotal study is to demonstrate long-term safety and efficacy of hypoglossal nerve stimulation to treat obstructive sleep apnea (OSA) using the Inspire II system and to support market release in the United States, Europe and…
The primary objective of this study is to analyze synchrony between ventilator and upper airways in COPD patients.Secondary objectives are to investigate whether the level of support and the triggering mode of noninvasive ventilation induces or…
This Phase II trial aims to:1 Test the predictive value of Zr89 Cetuximab uptake in vivo for treatment specific outcome 2 Explore the impact of dose redistribution on loco-regional control and disease free survival.If individualized treatment…
In this study the relation of OSAS with functional status and cognition, and the effect of treatment with CPAP on outcomes of rehabilitation in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between…
1. To investigate whether an adjusted mode of APAP can improve patients adherence in comparison to fixed CPAP in present-day PAP therapy of OSAHS patients.2. To investigate the agreement between the parameters of the CPAP devices and the polygraphy…
The aim of the project is to improve adherence to inhaled corticosteroids in children with asthma by using a Real-Time Medication Monitoring system (RTMM) and SMS alerts and to study weather improved adherence has an effect on asthma control and…
The purpose of this pilot study is to evaluate the feasibility, efficacy, safety of and patients* compliance to an OA-CPAP for planning a main randomised controlled study. The main objective is to investigate if a patient is treated effective,…
To assess the efficacy of reducing the sleep time in supine posture with positional therapy using the Z-cushion compared to compared to delay of treatment in patients with mild and moderate positional OSAS.
In this study the effect of SAS and the treatment with CPAP on cognitive functioning, fatigue and mood in stroke patients will be investigated. The main research questions are: 1) Is there a relationship between (the severity of) SAS and cognitive…
Primary ObjectiveTo determine the influence of treatment for OSA opioid-induced respiratory depression (minute ventilation (Vi); tidal volume (Vt); respiratory rate (RR); end-tidal pCO2; SpO2).Secondary ObjectivesAim 2: To determine the influence of…
The objectives of the study are as follows:*1. To assess the effectiveness of inhaled PA101 delivered via eFlow high efficiency nebulizer for treating chronic cough. Improvements in chronic cough will be assessed by measuring the change from…
This study consists of two research questions: 1. Which treatment (INCS on daily bases versus INCS on demand or versus oral antihistamines on demand) is most effective in reducing nasal symptoms and ocular symptoms in children with mild to moderate…
To compare the cost-effectiveness and effectiveness of MRA therapy versus CPAP therapy in patients with moderate OSAS.
PRIMARY OBJECTIVES * To evaluate the efficacy of lebrikizumab compared with placebo as measured by theability of patients to achieve lower daily doses of OCS while maintaining control oftheir asthma* To evaluate periostin as a predictive biomarker…