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New Therapies for bone and cartilage defects using bone marrow

The aim of the basic research in the laboratory is to develop new treatments to repair large bone defects, repair cartilage defects or inhibit the progression of osteoarthritis (cartilage degeneration). We focus on the following questions:1.How can…

*Does maintaining endotracheal tube cuff pressures at 20 mm Hg prevent dysphagia and hoarseness after anterior cervical spine surgery?*
A randomised controlled trial.

To determine if adjusting endotracheal tube cuff pressure after placement of a retractor during anterior cervical spine surgery prevents postoperative dysphagia. Furthermore laryngo-tracheal complaints (hoarseness and sore throat) will be scored.

Endoscopic evaluation of the paediatric airway after prior prolonged (>24 h) tracheal intubation, a multicenter study.

The first objective of this study is to evaluate by direct laryngo-tracheoscopy the possible role of cuffed versus uncuffed tracheal tubes in producing airway injury in infants and children who were previously more than 24 hours intubated. The…

E-health for optimization of the multidisciplinairy COPD care

Primary Objective: Can an e-Health application, based on objective measurements, maintain the daily physical activity of COPD patients after a period of rehabilitation?Secondary Objective(s): • Are COPD patients motivated to use the e-Health…

Prospective cohort study on the effect of surgical treatment of obstructive sleep apnea syndrome on blood pressure (and other cardiovascular risk factors).

In The Netherlands 2% of women and 4% of men suffer from Obstructive Sleep Apnea Syndrome (OSAS). NCPAP, the gold standard therapy for moderate to severe OSAS has been shown to reduce blood pressure in OSAS. NCPAP therapy is however hampered by…

*Prospective cohort study on the prevalence of obstructive sleep apnea in patients with head and neck cancer treated with either radiotherapy, chemoradiation or surgery*

The primary objective is to evaluate the percentage of the study population who have OSAS before and after treatment and the severity of it. A second objective is to correlate the prevalence of OSAS with different tumour sites and stages, as well as…

Perioperative decongestion and hemostasis, and postoperative analgesia for FESS after intranasal application of cocaine, tetracaine-oxymetazoline or ropivacaine-oxymetazoline

Het bestuderen en vergelijken van cocaïne, tetracaïne-oxymetazoline en ropivacaïne-oxymetazoline wat betreft de peroperatieve decongestie en hemostasis en postoperatieve analgesie die zij bieden bij FESS. Study and compare the peroperative…

Further development and validation of the daily hay fever forecast by symptom monitoring using modern information- and communication technology

1. To investigate whether the currently used hay fever forecast correlates with the symptoms that grass pollen allergic patients report directly using a new communication system that allows direct control, and whether the model can be improved.2.…

Prevalence of Obstructive Sleep Apnea (OSA) after treatment for advance stage head and neck cancer

1. To evaluate the prevalence of obstructive sleep apnea (OSA) in patients after treatment for advanced stage head and neck cancer2. To identify subgroups with higher risk of OSA within this cohort (e.g. tumor site and treatment type)3. To evaluate…

Pre-emptive tocilizumab in hypoxic COVID-19 patients, a prospective randomized trial

The aim of the study is to assess whether early administration of the drug tocilizumab in SARS-CoV-2 infection (COVID19 - coronavirus) can prevent the risk of death and mechanical ventilation (assisted respiration by a ventilator).