16 results
The primary objective is to evaluate whether 2.5 µg VD3 analogue (Zemplar® * Abbvie) in multiple subcutaneously administered doses induces a more favourable (read: anti-inflammatory) systemic immune modulation both in general parameters and allergen…
Investigate the prevalence of rhinosinusitis and/or nasal polyps in adult patients with Cystic Fibrosis. Also several aspects of sinonasal disease are investigated; quality of life, correlation between phenotype and genotype, microbiology, anatomy…
Investigation of the prevalence of sinonasal disease on CT-sinus in children with Cystic Fibrosis at different ages. This study will focus especially on the onset of sinonasal pathology in Cystic Fibrosis in relation to the development of the…
Primary objectives:1. To analyze the exact pathogenic mutations in the TCOF1 gene in TCS 2. To determine the severity, prevalence, natural course within the cohort TCS patients and potential metabolic and physical effects of OSAS in TCSSecondary…
To assess the normal nasal microcirculation in vivo. Also, this research may lead to a better understanding of the pathophysological mechanisms operative in nasal dysfunction. It may help us to differentiate between aetiology of different disorders…
Evaluation of the three-dimensional airway with a Conebeam CT(CBCT) scan to evaluate the upper-airway's in patientis with different degrees of severity of OSAS.
Analyze the correlation between change in EELV with change in MIF50
To assess 1. the burden of allergic disease across Europe*s aging population2. the association of severe asthma with potential risk factors and their impact on lung function decline over time3. the association of asthma severity with sex hormone…
Primary aim is to study electronically measured compliance to inhaled corticosteroids (ICS) in a multicultural population of children with asthma in Amsterdam. A secondary aim will be to compare electronical data on compliance with parent reports.
Analyze the correlation between change in EELV with change in MIF¬50
1. To integrate ENT specialists into the GA²LEN project in co-operations with internal medicine, allergists and pneumologists.2. To characterize patients with upper airway diseases on the basis of clinical parameters, infectious agents, inflammatory…
To investigate the changes in facial- and hand analysis in patients with acromegaly as a result of medical treatment and pituitary surgery, and to investigate the changes in relational proportions between facial- and hand structures, incidence and…
Nasal mucus proteins have different origins and production sites and gene expression does not necessarily result in functional metabolites. The aim of this proposed project is to try and analyze in a holistic proteomic approach the response to…
Primary objective:To investigate the dose - (clinical) response relationship and therapeutic window of biologics in the treatment of CRSwNP.Secondary objectives:- To investigate the effect of biologics on the sensibilisation pattern of specific IgE…
Primary Objective: • To determine the prevalence of NHR and BHR and determine the relationship between them in patients with chronic allergic and non-allergic rhinitis and compare with controls.Secondary Objective(s): • To determine differences in…
To assess the degree of arterial wall inflammation as measured by 18F-FDG PET/CT in subjects with OSAS and to further elucidate the pathophysiological mechanisms responsible for the increase in atherosclerosis in these patients.