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A randomised, double-blind, parallel group PhIII study to assess the clinical efficacy and safety of 100 mg SC Mepolizumab as an add on to maintenance treatment in adults with severe bilateral nasal polyps (study 205687, SYNAPSE)

Primary:To evaluate the efficacy of 100mg mepolizumab compared to placebo.Secondary:The impact on actual nasal surgery. Further efficacy assessment. Quality of life.

Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

The effectiveness of device-driven Expiratory Muscle Strength Training (EMST) in total laryngectomy patients; A pilot study.

The main purpose of this study is to examine the effects of expiratory muscle strength training (EMST) in subjects who have undergone a total laryngectomy. In this pilot study outcomes in pulmonary function, functional exercise capacity, vocal…

nvt

nvt

A randomized, double-blind, placebo-controlled, double-dummy study to determine the safety/tolerability of a simultaneous subcutaneous treatment of BM41 and vitamin D3 in patients with moderate to severe allergic rhinitis/ rhinoconjunctivitis caused by birch pollen.

Secondary objectives:The secondary objectives include demonstration of clinical efficacy of SCIT with BM41 alone, with BM41 plus VD3 and with VD3 alone, all three compared to placebo. Efficacy will be analysed for the upper airways by titrated nasal…

Xylitol/saline nasal irrigations in patients with CRS without polyps, a multicenter double-blind, randomized study in 66 subjects with CRS without polyps

In this study we will compare the therapeutic value of saline only versus xylitol/saline nasal irrigations in patients with CRS without nasal polyposis (CRSsNP). We will investigate several parameters by means of 2 different questionnaires and…

Assessment of cardiovascular risk in patients with severe obstructive sleep apnea syndrome

To assess the degree of arterial wall inflammation as measured by 18F-FDG PET/CT in subjects with OSAS and to further elucidate the pathophysiological mechanisms responsible for the increase in atherosclerosis in these patients.

Healthy volunteer studies for development of imaging techniques for motion management in MR-guided adaptive radiotherapy

Development of new imaging techniques for MR-guided motion management in the presence of respiratory motion