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Efficacy of Single inhaler Maintenance And Reliever Therapy (SMART) with Spiromax® budesonide/formoterol versus fixed dose treatment with Diskus® fluticasone/salmeterol in COPD

This research proposal aims to investigate the efficacy of the SMART approach with budesonide/fomoterol versus fixed dose treatment with fluticasone/salmeterol in patients with COPD.

The predictive value of the acute effect of montelukast on an exercise challenge test for the outcome of longterm treatment with montelukast

What is the correlation between change in % fall in FEV1 (*FEV1) after an exercise challenge 20h after a single dose of montelukast and after 4 weeks of treatment with montelukast?

Study evaluating ease of use, preference and satisfaction of two different Fluticason/salmeterol inhalers in asthma or COPD patients

To assess the percentage of COPD and asthma patients correctly (all critical items correct) using the Accuhaler/Diskus vs Elpenhaler inhaler devices after reading the package insert. Also satisfaction with and preference for an inhaler will be…

The predictive value of the acute effect of beclomethasone on a mannitol challenge test for the outcome of longterm treatment with beclomethasone

What is the correlation between change in Mannitol PD15 (provoking dose of mannitol to cause a >= 15% fall in FEV1 ) 6h after a single dose of beclomethasone and after 4 weeks of treatment with beclomethasone?

The Clinical Effectiveness of Fluticasone Furoate/Umeclidinium
Bromide/Vilanterol in a Single Inhaler (TRELEGY ELLIPTA) when Compared
with Non-ELLIPTA Multiple Inhaler Triple Therapies in COPD Patients within a Usual
Care Setting.(study 206854)

Primary:To compare the effectiveness of TRELEGY ELLIPTA with non-ELLIPTA MITT for the impact of COPDon wellbeing and daily life after 24 weeks* treatment. Secondary:To compare the effectiveness of TRELEGY ELLIPTA with non-ELLIPTA MITT on lung…

The predictive value of the acute effect of beclomethasone-dipropionate on an exercise-challenge test for the outcome of longterm treatment with beclomethasone-dipropionate in childhood asthma.

This study aims to investigate if there is a correlation between the severity of bronchoconstriction after an exercise challenge test 6h after a single dose of Qvar and after 4 weeks of treatment with Qvar, in order to know if the respons to a…

Measuring the doserespons of Salbutamol (Ventolin) by means of a lungfunctiontest

n.v.t.

The effect of twice daily aclidinium bromide/formoterol fumarate 340/12 mcg vs. once daily tiotropium 'respimat' 5mcg on static and dynamic hyperinflation in patients with COPD during 24 hours.

Therefore we aimed to study the 24 hour effect of twice daily aclidinium/formeterol versus once daily tiotropium on serial static and dynamic lung hyperinflation measurements, as well as (24 hour) symptoms and sleep quality. Tiotropium was chosen as…

A strategy of bacterial eradication to prevent exacerbations of COPD in the frequent exacerbator phenotype population (GOAL study), a prospective randomized controlled pilot study

Investigation of the impact of a treatment consisting of inhalation antibiotics and prolonged oral antibiotic course during a bacterial exacerbation on the prevention of further exacerbations.

An open label, randomised, parallel group clinical study to evaluate the effect of the Connected Inhaler System (CIS) on adherence to Relvar/Breo ELLIPTA therapy, in asthmatic subjects with poor control (study 207040)

Primary:To compare the effect of 6 months use of the CIS on adherence to ELLIPTA maintenance therapy when both the subject and the HCP are supplied with data from the maintenance sensor versus no data supplied to the subject and HCP (Arm 1 vs Arm 5…

A cluster Randomised Controlled Trial of the effectiveness, usability and acceptability of a smart inhaler programme in asthma patients: the ACCEPTANCE study

This study aims to investigate the effectiveness of a smart inhaler based asthma self-management programme on medication adherence in adults with partially controlled or uncontrolled asthma. Secondary objectives are 1) to evaluate the effect of the…

A40 EFL Registry: A Multicenter Prospective Study to Determine the Role of EFL in Patients with Chronic Obstructive Pulmonary Disease (COPD) Receiving Home Mechanical Ventilation
Protocol ID: SRC_HRC_VectorEURegistry_2019_10820

a. To determine what proportion of COPD patients demonstrate EFL during NIV useb. To determine the range of EPAP necessary to overcome EFLc. To determine longitudinal change of EFL with time and interaction with exacerbationd. To describe the…

Triple therapy effectiveness in COPD patients with characteristics of asthma: A pragmatic Primary Care trial - The TRACkER trial

This study has been transitioned to CTIS with ID 2023-508300-37-00 check the CTIS register for the current data. To investigate the effectiveness of triple therapy (ICS/ long-acting beta 2 agonist (LABA)/long-acting muscarine antagonist (LAMA)) on…

Study Evaluating the Added Value of the Triple Feedback Mechanism of the NEXThaler by focusing on Critical ErrOrs, PRefeRencEs and SatisfaCTion with the NEXThaler versus a non-feedback providing dry powder inhaler in Asthma an COPD patients

This study is designed to assess the proportion of asthma and COPD subjects making critical and non-critical errors in using NEXThaler compared with Turbuhaler after 4 weeks of clinical use. This will give insight in the importance of triple…

Effect of inhaled corticosteroid tapering in obese T2-low asthma patients on asthma control and quality of life: an investigator-initiated, multicenter, non-inferiority, open label crossover trial with open label extension

Primary Objective To demonstrate that ICS can be safely withdrawn in T2-low asthma patients with obesity in secondary care (i.e. without loss of asthma control).Secondary Objectives1. To determine predictive factors for successful ICS withdrawal.2.…