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Exercise-induced left ventricular diastolic dysfunction in COPD patients with a symptomatic limitation to exercise

The primary aim of this observational study is to determine the occurrence of exercise-induced left ventricular diastolic dysfunction (LV-DD) in symptomatic COPD patients with a normal echocardiography at rest. And, secondly, to study the…

Long-term extension, multi-centre, multi-national study to evaluate the safety and tolerability of oral BAY 63-2521 (1 mg, 1.5 mg, 2 mg, or 2.5 mg tid) in patients with Chronic Thromboembolic Pulmonary Hypertension (CTEPH).

BAY 63 2521 is a stimulator of the soluble guanylate cyclase (sGC) and is intended for the treatment of cardiovascular diseases, especially pulmonary hypertension (PH).To assess the longterm safety and tolerability of oral BAY 63-2521 in patients…

Registry of Sarcoidosis Associated Pulmonary Hypertension (RESAPH)

We propose to develop a multicenter registry of sarcoidosis associated pulmonary hypertension (SAPH). With this registry, we will characterize the demographics, clinical course, hemodynamics, pulmonary physiology, and disease management of…

MRI analysis of PAVM's

To demonstrate that MRI is as good in the detection of clinically relevant PAVM as the CT.

A single-center, open-label, randomized, two-period, two-treatment, crossover study in healthy male subjects to demonstrate bioequivalence of 1600 mcg selexipag administered as eight tablets of 200 mcg (reference drug) or as single tablet of 1600 mcg (test drug)

- To demonstrate bioequivalence of test drug and reference drug - Safety and tolerability- Investigate phamacokinetic properties of selexipag and its metabolite

AMB116457: An open-label extension study of the long-term safety, tolerability and efficacy of ambrisentan in subjects with inoperable chronic thromboembolic pulmonary hypertension (CTEPH)

Primary: to assess the longterm safety and tolerability of ambrisentan 5mg in subjects with inoperable CTEPH. Secondary: to collect supportive efficacy data.

An open-label phase IIIb study of riociguat in patients with in-operable CTEPH, or recurrent or persisting PH after surgical treatment who are not satisfactorily treated and cannot participate in any other CTEPH trial

Objectives of the study are to assess safety, tolerability and clinical effects of riociguat and provide access to inoperable patients for a condition (CTEPH) with unmet medical need.

An Open-Label Extension Trial of UT-15C SR in Subjects with Pulmonary Arterial Hypertension

To provide, or continue to provide, UT-15C SR for eligible subjects who participated in protocols TDE-PH-301 or TDE-PH-302 or TDE-PH-308 or additional UC-15C SR clinical protocols.To assess the long-term safety of UT-15C SR in these subjects through…

An open-label extension of study AC-066A301 investigating the safety and tolerability of ACT-385781A in patients with pulmonary arterial hypertension (PAH)

To assess safety and tolerability of EFI patients with PAH.

An extension study to QTI571A2301 to evaluate the longterm safety, tolerability and efficacy of oral QTI571 (imatinib) in the treatment of severe pulmonary arterial hypertension.

Primary: To evaluate the long-term safety and tolerability of QTI571.Secondary: * Continue to evaluate the long-term efficacy of QTI571 as measured by the change in6MWD from baseline.* Continue to assess time to clinical worsening (TTCW) endpoints…

An open-label, long term extension study for treatment of pulmonary arterial hypertension in paediatric patients aged 8 years up to 18 years who have participated in AMB112529 and in whom continued treatment with ambrisentan is desired (AMB114588)

Primary: Longterm safety and tolerability of 2 dosages of ambrisentan. Secundary: Supportive efficacy data.

The effect of N-acetylcysteine and ascorbic acid on pulmonary arterial pressure and ventilation during normoxia, hypoxia and hyperoxia and total oxidant capacity.

In this study we will therefore investigate the influence of hypoxia and anti oxidants on HVR and HPV.

Myocardial function, oxygen consumption and efficiency assessment in the right ventricle of patients with idiophathic pulmonary hypertrophy using positron emission tomography.

The study investigates the role of the RV efficiency in the deterioration of RV function to failure in PH (measured with stroke volume index as the parameter of RV function); efficiency will be related to MVO2, alterations in substrate metabolism…

Structural and Functional Microcirculatory Aspects of Patients with (suspected) Connective Tissue Disease and Pulmonary Arterial Hypertension

The proposed project focuses on: a) implementation of an improved, standardized method for performing quantitative nailfold capillaroscopy to visualize morphological patterns and evaluate its diagnostic use in patients with (possible) CTD and…

A randomized, open label study comparing safety and efficacy parameters for a high and a low dose of ambrisentan (adjusted for body weight) for the treatment of pulmonary arterial hypertension in paediatric patients aged 8 years up to 18 years (AMB112529)

Primary: Safety and tolerability of 2 dosages of ambrisentan. Secundary: Efficacy and PK.

The Effects of Epidermal Growth Factor Receptor (EGFR) Inhibition on Pulmonary Arterial Hypertension Associated with Systemic Sclerosis
A phase II controlled open-label safety and efficacy study.

The first objective is to evaluate the safety of cetuximab in patients with scleroderma associated PAH. The secondary objective is to assess efficacy.

Gallium-67 scintigraphy in right ventricular disease

To study whether inflammmation plays a role in patients with RV disease, and can be detected with Gallium-67 scintigraphy

Efficacy and safety of home treatment versus in hospital treatment with LMWH in patients with non-massive pulmonary embolism

1. To evaluate the efficacy and safety of out of hospital treatment with LMWH and Vitamin K antagonists in consecutive patients with objectively proven acute non-massive pulmonary embolism2. To perform a health economics evaluation in all patients3…

Restoration of cardiac function and regional pulmonary blood flow in chronic thromboembolic pulmonary hypertension after pulmonary endarterectomy assessed during exercise by magnetic resonance imaging

To assess, by use of MRI measurements during exercise, the level of restoration of cardiac function, and to study whether excercise limitation in CTEPH patients after a hemodynamically succesful PEA is caused by an impaired RV stroke volume response…

Exercise training in patients with idiopathic Pulmonary Arterial Hypertension

1. Does exercise training improve muscle function and exercise tolerance in patients with IPAH?2. Does exercise training in IPAH result in morphological and biochemical changes of the quadriceps muscle?3. Does exercise training in IPAH result in…