50 results
Main question: What is the lung function of late preterm births compared with children born at term at age 12? Sub-questions: - Which respiratory symptoms in late preterm infants at age 12?
To evaluate the safety and efficacy of lucinactant for inhalation, in comparison to nasal continuous positive airway pressure (nCPAP) alone, inpreterm neonates with RDS, as assessed by the time to, and incidence of, respiratory failure and/or death…
To identify alternative dEMG electrode positions in preterm infants for cardio-respiratory monitoring.
To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).
Recently, population PK/PD modeling and simulation studies have enabled the development of evidence-based individualized dosing schemes for children with a limited number of subjects, thus improving drug safety and efficacy. The application of PK/PD…
To assess the accuracy and cost-effectiveness of PO screening for CCHD in the Dutch perinatal care system.
To describe the synchronicity of nIPPV respiratory support with spontaneous diaphragm activity and the effect of asynchrony of mechanical inflations and spontaneous breaths on lung volume, mechanical parameters and diaphragm activity in preterm…
The main objective is to improve exercise tolerance. Secondary objectives are: 1) improvement of motor function development, daily physical activity, quality of life, self perception of motor competence, and participation; 2) evaluation of cost…
The objective of this study is to investigate ABG, CBG and VBG (or parts of the blood gas analysis) in infants.
The main objective of this study is to determine if Low-Flow is non inferior in reducing apneic spells compared to caffeine. Secondary objectives are investigating if these treatments have an effect on the need of supplemental ventilation and on the…
Aim of total study:Diagnosing all components of RS in an objective mannerAim of present substudy:Increasing the reliability and decreasing the burden of the method with which glossoptosis can be determined in newborns with RS
The primary objective is to determine if echocardiography in combination with plasma biomarkers can be used as a potential predictor for pulmonary hypertension. The secondary objectives are assessment of a potential correlation between…
In this multicenter trial we compare resuscitation of preterm neonates with either 5 cm H2O PEEP or 8 cmH2O PEEP. We think resuscitation with 8 cmH2O PEEP results in a better outcome compared to resuscitation with 5 cmH2O PEEP.
Primary Objectives: The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for PPHN. Secondary Objectives: *…
The primary objective is to obtain insight in regional differences in lung volume and ventilation distribution during apnea of prematurity and its farmacological treatment. Furthermore, the effect on these parameters due to position changes and non-…
Primary Objective: To identify new markers in BPD, in particular in sphingolipid- and oxylipin profiles in tracheal aspirates.Secondary Objective(s): To predict the development of BPD in preterm infants by the use of metabolomic analysis of the…
To study whether microcirculatory perfusion is improved by ECMO. Perfusion will be studied before & after ECMO start, during ECMO weaning and before & after ECMO stop. To study the precictive value of perfusion and its correlation…
Does the use of NIPPV in ELBW infants (<30 wks of GA and BW<1000gr) requiring non-intubated respiratory support in a Level III perinatal center increase the rate of survival without BPD when compared to nCPAP.
Is a higher dose of aerosolised salbutamol as a treatment for preterm infants suspected for developing BPD more effective than a lower dose on short-term clinical effects?
Monitoring the haemodynamic status during lung recruitment.