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Pulmonary Hypertension in preterm children born at gestational age <30 weeks: Prevalence, risk factors and outcome.

Is to identify the incidence and prevalende of PH in premature born infants. In addition we will identify possible risk factors for the development of PH and we want to determine the prognosis and survival of these patients. PrimaryTo determine the…

MULTICENTRE RANDOMISED CONTROLLED TRIAL
OF MINIMALLY-INVASIVE SURFACTANT THERAPY IN
PRETERM INFANTS 25-28 WEEKS GESTATION
ON CONTINUOUS POSITIVE AIRWAY PRESSURE

To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).

A MULTINATIONAL, MULTICENTER, MASKED, RANDOMIZED, CONTROLLED
STUDY TO ASSESS THE SAFETY AND EFFICACY OF LUCINACTANT FOR
INHALATION IN PRETERM NEONATES 26 TO 32 WEEKS GESTATIONAL AGE
WITH RESPIRATORY DISTRESS SYNDROME.

To evaluate the safety and efficacy of lucinactant for inhalation, in comparison to nasal continuous positive airway pressure (nCPAP) alone, inpreterm neonates with RDS, as assessed by the time to, and incidence of, respiratory failure and/or death…

Continuous Regional Analysis Device for neonate Lung (CRADL)

To design and test an EIT device and interface for infants based on a modified adult device (Continuous Regional Analysis Device for neonate Lung (CRADL) project). More specifically this protocol focusses on collecting EIT recordings in infants…

Safety and feasability of Predictive Intelligent Control of Oxygenation (PRICO) on the Neonatal Intensive Care Unit (NICU)

To test the safety and feasibility of a closed loop controller of the FiO2 based on the measured SpO2 in a NICU setting.

Long-term Outcome of Bronchopulmonary Dysplasia * Focus on Cardiovascular Health

Primary objective: Part A: MR cardiopulmonary exercise protocol validation: To validate the protocol of the CMR-ergometer against conventional ergometers in young healthy adultsPart B: CMR exercise study To examine cardiorespiratory structure and…

Minimally invasive surfactant therapy and diaphragm activity in preterm infants

To determine the effect of MIST on the electrical activity of the diaphragm.

Work of breathing and respiratory control in preterm infants

To determine the influence of different nCPAP levels on WOB and electrical activity of the diaphragm and to investigate if these parameters are correlated in preterm infants.