72 results
The aim of this study is to test the hypothesis that using nasal tube as interface during resuscitation/stabilisation of preterm infants at birth is more effective compared to mask.
Does the use of NIPPV in ELBW infants (<30 wks of GA and BW<1000gr) requiring non-intubated respiratory support in a Level III perinatal center increase the rate of survival without BPD when compared to nCPAP.
Primary objective- Survival without BPD at 36 weeks gestational age (GA)Secondary objectives- Neurodevelopment at a corrected age of 18-22 months- Adverse treatment effects- Mortality at 36 weeks gestational age- BPD incidence at 36 weeks…
The main objective of this study is to determine if Low-Flow is non inferior in reducing apneic spells compared to caffeine. Secondary objectives are investigating if these treatments have an effect on the need of supplemental ventilation and on the…
Aim of total study:Diagnosing all components of RS in an objective mannerAim of present substudy:Increasing the reliability and decreasing the burden of the method with which glossoptosis can be determined in newborns with RS
The main objective is to improve exercise tolerance. Secondary objectives are: 1) improvement of motor function development, daily physical activity, quality of life, self perception of motor competence, and participation; 2) evaluation of cost…
To test the hypothesis that observing the data and waveforms displayed on an RFM during the provision of positive pressure ventilation to preterm infants at birth will increase the proportion of tidal volumes within a predefined *safe range* of 4 -…
Primary Objectives: The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for PPHN. Secondary Objectives: *…
The objective of this study is to investigate ABG, CBG and VBG (or parts of the blood gas analysis) in infants.
Monitoring the haemodynamic status during lung recruitment.
The first aim of this study is to obtain insight in the physical fitness of ex-preterms. The second aim is to study the influence of the daily activity pattern of the children on physical fitness. The third aim is to study the attitude of parents…
The primary objective is to obtain insight in regional differences in lung volume and ventilation distribution during apnea of prematurity and its farmacological treatment. Furthermore, the effect on these parameters due to position changes and non-…
To compare the occurrence of significant mask leak when using a nasal mask versus a facemask in preterm infants needing positive pressure ventilation.
Primary Objective: To identify new markers in BPD, in particular in sphingolipid- and oxylipin profiles in tracheal aspirates.Secondary Objective(s): To predict the development of BPD in preterm infants by the use of metabolomic analysis of the…
Is a higher dose of aerosolised salbutamol as a treatment for preterm infants suspected for developing BPD more effective than a lower dose on short-term clinical effects?
The aim of this study is to develop a safe and fast MRI protocol for the imaging of neonatal and pediatric BPD patients. This METC application addresses the first part of the MRI- BPD project: *Ventilation, Inflammation, perfusion and structure in…
To determine the feasibility of umbilical PO for HR measurements after cord clamping in infants needing stabilization at birth and to compare this with standard PO on the right hand.
This study has the following objectives:1) To assess if dEMG measurement is feasible during pulmonary transition in the delivery room* Does the signal quality (expressed in heart rate and respiratory rate) of dEMG during the transition agree with…
Primary ObjectivesPart A:To determine the pharmacokinetics (PK) of intramuscular (IM)administrations of REGN2222Part B:To demonstrate the efficacy of REGN2222 in preventing medicallyattended respiratory syncytial virus (RSV) infections (subjects…
To design and test an EIT device and interface for infants based on a modified adult device (Continuous Regional Analysis Device for neonate Lung (CRADL) project). More specifically this protocol focusses on collecting EIT recordings in infants…