19 results
To assess whether Th17 cells play a central role in COPD, CF and pneumonia pathogenesis
D1. Comparing the made distance in meters within a fixed time between a walker and a walk-bike used by COPD patients.D2. Comparing the walking time and distance on an outdoor track between a walker and a walk-bike used by COPD patients.
The aim of this study is to identify direct markers of muscle and adipose tissue hypoxia in COPD and CHF patients in relation to the altered muscle oxidative phenotype and the putative mediators HIF-1α and PPARs/PGC-1. Insight in the underlying…
The objective of the current study is to investigate the individual sensitivity for the development of ILD after exposure to various triggers. Main focus will be the differences in the formation of and the protection against ROS as well as the…
Objectives1. to determine whether nebulization of heparin decreases coagulation activation in the pulmonary compartment (i.e. BAL fluid)2. to determine whether nebulization of heparin decreases pulmonary vascular permeability
To evaluate a result oriented smoking cessation program in which treatment goals are signed up in a doctor-patient contract.
To determine feasibility and reproducibility of MicroRint pulmonary function testing in 50+ people with different levels of intellectual disability.
This pilot study will investigate whether patients with both COPD and CHF who participated in a community based reactivation programme have a higher exercise capacity and a better health related quality of life after the programme in comparison with…
Research questions:What is the current prevalence of latex allergy among operating room employees from Erasmus Medical Centre, Rotterdam? Is the sensitisation prevalence significantly lower compared to the prevalence before introducing non powdered…
Aim of the study is to evaluate RPL554*s safety in healthy, non-asthmatic subjects and consequently to assess RPL 554 safety and efficacy in allergic asthmatics and in allergic rhinitics.
This pilot study aims to investigate sexual wellbeing, sexual functioning and sexual health care need within four groups of patients with major illness (COPD patients, gynaecological patients, pelvic care patients, and patients with depressive…
What is the clinical course of m. quadriceps muscle function in COPD?
1a. To compare metabolic response during ADL between patients with moderate to severe COPD and healthy age-matched control subjects.1b. To compare symptom Borg scores for dyspnoea and fatigue and heart rate during ADL between patients with moderate…
To evaluate the potential attenuating effects of a one-week supplementation with 2 x 250 mg caffeine per day on blood biomarkers of systemic inflammation in COPD patients.
Analyze the protective effect of levocetirizine (LEV), through the direct antagonism of airway H1 receptors and the inhibition of the release or production of other inflammatory mediators, against exercise induced airway obstruction.
To assess long-term safety and tolerability of bosentan in patients with IPF.
Objective: To investigate posture dependent small airway obstruction in subjects with obesity. To study the capacity of FOT as a measurement tool for small airways obstruction.
To establish platelet function and primary hemostasis during lung transplantation
1. Respiratory physiologyDoes severity of ventilatory impairment during ADL increase in patients with respectively COPD GOLD stages II, III and IV?2. Systemic inflammationDo ADL in COPD patients lead to an increase in systemic inflammatory markers?