26 results
The primary objective for this study is to compare the level and time course of the patient work-of-breathing during PS ventilation with the work-of-breathing during SIMV-PS ventilation with a lower rate of breaths per minute delivered by the…
The objective of the trial is to confirm efficacy and a favorable benefit-risk ratio for BIBF 1120 in the treatment of IPF at the dose of 150 mg bid compared to placebo.
* To investigate the effect of roflumilast 500 µg tablets once daily versus placebo on exacerbation rate, and pulmonary function and major adverse cardiovascular events (MACE) in COPD patients who are concomitantly treated with a fixed combination…
The primary objective of this study is to evaluate efficacy and safety. Secondary objectives: PK, PK-PD.
To assess the prevalence of BHD among patients with spontaneous sporadic and familial pneumothorax.
The present study aims at comparing the post-operative lung injury of a lung*protective mechanical ventilation strategy (with the use of higher levels of PEEP and intra*operative recruitment maneuvers) with conventional mechanical ventilation (lower…
Primary objective:- To evaluate the effects of a 10 day-course of prednisolon on coagulation and fibrinolysis parameters in patients with mild-moderate astma, patients with severe asthma, and healthy controls.Secondary objectives:- To compare the…
The aims of the current study are:1. Demonstrate that during noninvasive ventilation a patient with acute respiratory failure is in better synchrony with the ventilator during NAVA compared to PSV mode.2. Demonstrate that the Servo-i ventilator is…
Primary objective: To assess the efficacy of reducing the sleep time in supine posture with positional therapy using the position training device compared to the sleep position band in patients with mild and moderate positional OSAS.Secondary…
Primary objective: * To study differences in global lung aeration before and during spontaneous breathing during mechanical ventilationSecondary objective:* To study the work of breathing (WOB) under various pressure support (PS) levels in…
To evaluate the mechanism of action and effecacy of the Lung Volume Reduction Coil to improve QOL pulmonary function for homogeneous emphysema subjects with severe hyperinflation.
The objective of this study is to assess the efficacy and safety of 52 weeks once daily treatment with orally inhaled tiotropium plus olodaterol fixed dose combination compared with the individual components tiotropium and olodaterol (delivered by…
To investigate the efficacy of repeated daily doses of nebulised RPL554 (0.018 mg/kg) by assessing the effect on FEV1 at day 1, 3 and 6 after daily inhaled doses of nebulised RPL554 0.018 mg/kg (6X) in 16 allergic asthmatics.
The primary objective is to establish the point prevalence of Airflow Limitation (AL) compatible with COPD, in current/former smokers, with established cardiac diseases, in Europe. Secondary Objectives are: • To establish the point prevalence of AL…
Primary Objective: Which physiological impairments and complaints are present during activities of daily living in patients with mild COPD? Secondary Objective(s): Are physiological impairments and complaints during activities of daily living…
to assess patient's overall preference for the two inhaler devices in COPD patients after 2 weeks of dialy practice.
To investigate both the clinical and economical(-healthcare evaluation) improvement of BVR using best responder criteria in patients with severe COPD.
The primary study objectives are: (1) to determine whether an internet-based guided self-help intervention is effective in reducing symptoms of depression in glioma patients; (2) to determine the impact of the intervention on the HRQOL of both…
Evaluate the safety and technical feasibility of TLD Therapy in the treatment of patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD).
Efficacy and safety during 24 treatment weeks.