22 results
Effect on bone mineral density.
The primary objective is to study the level and time course of the end-expiratory lung volume during the individual incremental * decremental PEEP titration; the secondary objective is to study if there is a significant association between the end-…
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
Primary: Assess the effect of i.v. infusions of BYM338 on muscle volume of the thigh (assessed by MRI) at 4, 8, 16 and 24 weeks, compared to placebo, in COPD patients with pulmonary cachexia.Secondary: Effect on 6-minute walk test, safety and…
Clarify the effect of 5T polymorphism with or without another CF causing mutation on the other allele, on the CFTR function.
The primary outcome measure will be comparison of improvement in endurance of a work rate initially eliciting exercise limitation after 6 minutes (calculated from the power-duration relationship before and after training). We will also compare…
To assess if preoxygenation with 100% O2 or preoxygenation with 100% O2 and PEEP are different with respect to the development of atelectasis as determined by lung computed tomography.
Primary objective: To demonstrate that QVA149 (110/50 *g o.d.) is at least non-inferior to salmeterol/fluticasone (50/500 *g b.i.d.) in terms of rate of COPD exacerbations.Secondary objectives: Superiority in terms of exacerbation rate. Time to…
To assess the safety and effects of bronchoscopic intrabullous blood instillation in patients with bullous emphysema on lung function, quality of life measures, functional measures and CT measured lung volumes.
Efficacy and safety.
The primary aim of this project is to define the role exacerbations play in the pathophysiology of COPD. Moreover, the study has the aim to determine the long-term effects of PR and the natural course of the disease. The unique design of MCC will…
Intestinal Permeability during Respiratory insufficiency in patients with acute exacerbation of COPD
The primary objective of the present study is to investigate if the intestinal permeability is increased in patients with an acute COPD exacerbation. To investigate this objective, the following research question have been formulated:- Is intestinal…
Compare if once daily laba/lama treatment with two different dosages shows the same or better result on the 24 hr lungfunction than twice daily treatment of two different dosages with ICS/laba treatment. .
First Objective: Is the percentage of subjects that dynamic hyperinflate during activities of daily living larger in patients with mild COPD than in healthy controls?Second Objective(s): Will dynamic hyperinflation induced by activities of daily…
The objective of the proposed study (1237.25) is to evaluate maximal treatment effect in FEV1 and SGRQ after 12-weeks treatment with two different doses of tiotropium + olodaterol FDC (5*g/ 5*g and 5*g/ 2.5*g) by comparison with placebo in patients…
Efficacy and safety.
The primary objective of this study is to provide the LVRC procedure and safety and effectiveness follow up to qualifying subjects who were enrolled as Control Subjects in and completed the 12 month visit of the Lung Volume Reduction Coil Treatment…
The primary objective of this study is to compare the effect of a standard and early RM in newly intubated critically ill patients. The secondary objective is to determine the effect of an early RM on cardiac function. We hypothesize an early RM to…
The objective is to investigate whether environmental exposure to livestock farm emissions in the Netherlands poses a health risk among neighbouring residents.
The primary objective is to asses the association between the EELV measured with RIP and EELV volume measured with electrical impedance tomography (EIT). Secondary objectives include a) studying the association between the EELV measured with RIP and…