8 results
Evaluate whether CT lung densitometry and PWV associate with plasma DES concentrations. In addition, we want to determine whether certain other laboratory determinations in the blood and condensed exhalation vapor correlate with plasma DES.
This study has been transitioned to CTIS with ID 2024-514055-15-00 check the CTIS register for the current data. Primary: • Investigate the effectiveness and tolerability of methotrexate as first-line therapy in patients with pulmonary sarcoidosis…
Specific Aims: In children with severe PARDS:1. To compare the effects of prone positioning with supine positioning on ventilator-free days.2. To compare the effects of HFOV with CMV on ventilator-free days.Hypothesis: Children with severe PARDS…
The purpose of this study is to support the dose selection for the future development program of QBW251 by evaluating efficacy and safety of different QBW251 doses in patients with Chronic Obstructive pulmonary disease (COPD) with chronic bronchitis…
In the present pilot study, we intend to test phenotypic flexibility (Phenflex) in 20 clinically stable patients with COPD by exploring their response to a dietary challenge test before and after pulmonary rehabilitation. Moreover, the baseline…
Primary objective: To evaluate the efficacy of targeted lung denervation (TLD) in addition to optimal medical care to reduce moderate or severe exacerbations and related hospitalizations, compared with optimal medical care alone, in subjects with…
Overall aim: To evaluate the relationship between airway structure and function in patients with chronic bronchitis treated with metered cryospray (MCS).1) To identify the molecular and cellular targets of MCS treatment and determine the mechanistic…
The overall objective of this RCT is to determine the effectiveness and long-term outcome of an high PEEP strategy, aiming at preventing atelectasis, but avoiding an increase in driving pressure, during intraoperative ventilation. Specifically, this…