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A NOVEL observational longiTudinal studY on patients with a diagnosis or
suspected diagnosis of asthma and/or COPD to describe patient
characteristics, treatment patterns and the burden of illness over time and
to identify phenotypes and endotypes associated with differential outcomes
that may support future development of personalised treatment strategies

The primary objectives are:*To describe patient characteristics, treatment patterns and the burden of illness over time for individuals in clinical practice with a diagnosis, or suspected diagnosis,2of asthma and/or COPD. Data will be described for…

Development of a *two hit* in vivo autologous platelet transfusion model in healthy volunteers

To develop a *two hit* in vivo autologous PLTs transfusion model in healthy male volunteers

Driving pressure during general anesthesia for open abdominal surgery - a randomized controlled trial

The overall objective of this RCT is to determine the effectiveness and long-term outcome of an high PEEP strategy, aiming at preventing atelectasis, but avoiding an increase in driving pressure, during intraoperative ventilation. Specifically, this…

A double blind, randomized, placebo-controlled trial evaluating the efficacy and safety of BI 1015550 over at least 52 weeks in patients with Idiopathic Pulmonary Fibrosis (IPF)

The aim of this study is to evaluate the efficacy, safety and tolerability of BI 1015550 9 mg BID and 18 mg BID compared to placebo in patients with IPF, in addition to the patient's standard of care. The primary objective of this study is to…

A portable dyspnea RELIEF device for episodic breathlessness in COPD (PEP-buddy): effect on dyspnea severity and mechanism of action

Our primary objective is to investigate the change in dyspnea severity after 4 weeks of the use of the PEP-buddy. Secondary objectives are to investigate the patient satisfaction level and use of the device, the effect on quality of life and COPD…

COPD monitoring

The purposes of this feasibility study are: • to evaluate the correlation between COPD-related dyspnea and the EMG of respiratory muscles when simulating daily activities, to assess the dyspnea symptom in a more objective (measurable) way; • to…

Targeted lung denervation (TLD) with the Ryme Medical Lung Denervation System in patients with chronic obstructive pulmonary disease (COPD)

Primary ObjectiveThe primary objective of the study is to evaluate the safety of The Ryme Medical Lung Denervation System.Secondary ObjectivesThe secondary objective of the study is to evaluate the performance of The Ryme Medical Lung Denervation…

A Randomized, Sham Controlled, Double-blinded, Multi-center Trial to Evaluate the Efficacy of the VentFree Respiratory Muscle Stimulator to Assist Ventilator Weaning in Critically Ill Patients

The primary objective of the trial is to determine whether abdominal FES reduces the duration of invasive mechanical ventilation in critically ill adult patients compared to a sham control.The secondary objectives are to determine whether abdominal…

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial

This study is to investigate the safety and effectiveness of the AeriSeal system in limiting collateral ventilation within a target lung lobe. And to achieve lung volume reduction using Zephyur Vavles and assess lung function, hyperinflations and…

Bronchoscopic Release of Air Trapped in Hyperinflated Emphysematous Lung

Primary safety objective: The primary safety objective of the study is to assess the safety of the Apreo Endobronchial System for treatment of severe emphysema.

Calibration of Esophageal Balloon catheter in spontaneous and mandatory mechanical ventilation.

To obtain the best filling pressure of the Pes catheter in spontaneous mechanical ventilation, to obtain the esophagus elastance in spontaneous mechanical ventilation, and to compare the best filling pressures between the two modes (spontaneous and…

SWITCH-SAFE: Unraveling the (patho)physiological mechanisms and potential clinical benefits of an early switch from controlled to assisted ventilation

The overall aim is to unravel the (patho)physiological mechanisms and potential clinical benefits of a pre-specified early switch from controlled to assisted ventilation. The primary objective is to investigate the changes in regional lung stress…

Analysing cEllular bioenergetics aNd structural aDaptations in the qUadriceps muscle befoRe and After endobroNChial valve treatmEnt.

To investigate the physiological and structural adaptations of peripheral muscle function at a cellular level in response to EBV treatment.

Physiological effect High-flow Tracheal Oxygen on Viscosity of Airway Mucus and Respiratory Effort ain Patients Weaning from Invasive Mechanical Ventilation

Primary Objective: To determine the difference in change in sputum viscoelasticity on HME and HFTO during disconnection sessions from the ventilator in tracheotomised patients. Secondary Objective(s): 1. To determine the difference in respiratory…

The REDUCE EU Study - Endobronchial Thermal Liquid Ablation (ETLA) for the Treatment of Emphysema - A Pilot Study (CSP-12123)

The primary objective of the study is to assess the feasibility and safety of sequential ETLA treatment in patients with severe emphysema with hyperinflation. The secondary objective of the study is to assess efficacy of sequential ETLA treatment in…

Change in task-related oxygen uptake after bronchoscopic lung volume reduction with endobronchial valves

To investigate the change in exercise physiology during daily activities after EBV treatment.