296 results
The primary outcome measure will be comparison of improvement in endurance of a work rate initially eliciting exercise limitation after 6 minutes (calculated from the power-duration relationship before and after training). We will also compare…
Primary Objective: To identify new clinical phenotypes in patients with severe chronic obstructive pulmonary disease (COPD) using a cluster analysis.Secondary Objectives: To:- identify clinical phenotypes (based on e.g. lung function parameters,…
To assess if preoxygenation with 100% O2 or preoxygenation with 100% O2 and PEEP are different with respect to the development of atelectasis as determined by lung computed tomography.
Primary objective:To evaluate pulmonary function (FEV1) at 3 months following placement of Zephyr endobronchial valves in subjects with homogeneous emphysema.Secondary objectives:Evaluation of quality of life, exercise capacity, dyspnea incl. BODE,…
Primary objective: To demonstrate that QVA149 (110/50 *g o.d.) is at least non-inferior to salmeterol/fluticasone (50/500 *g b.i.d.) in terms of rate of COPD exacerbations.Secondary objectives: Superiority in terms of exacerbation rate. Time to…
Major objectives:- To determine the role of small airways abnormalities in the clinical manifestations of asthma;- To evaluate which (combination of) clinical methods best assesses the abnormalities of small airways and large airways disease in…
Primary: To demonstrate the superiority of NVA237 50 *g o.d. compared to placebo in addition to background therapy with long acting B2 agonist/ inhaled corticosteroid (* 800 *g/day of budesonide or equivalent) in terms of trough FEV1 after 26 weeks…
The purpose of this study is to compare the Metronome-Paced Hyperventilationtest (MPH) with cardiopulmonary exercise testing (CPET) in patients with COPD for detecting dynamic hyperinflation, thereby establishing the diagnostic accuracy for dynamic…
The study objective is to demonstrate the feasibility and safety (measured by the occurrence of serious adverse events) of the RejuvenAir System Radial Spray Cryotherapy in a population of subjects who are scheduled to undergo a planned lobectomy or…
PRIMARY OBJECTIVE:To determine the contractile strength of diaphragm fibers of COPD patients before and after in vitro exposure to CK-107. SECONDARY OBJECTIVE:To determine the contractile strength of latissimus dorsi fibers of COPD patients before…
The primary objective of this study is to evaluate efficacy and safety. Secondary objectives: PK, PK-PD.
To compare the efficacy and safety of 2.5 µg and 5 µg Tiotropium Inhalation Solution delivered by the Respimat® Inhaler with Tiotropium inhalation capsules 18 µg delivered by the HandiHaler®.
The primary objective of this study is to evaluate the dose response, dose interval, efficacy, and safety of GSK961081 by studying three QD doses and three BID doses in subjects with COPD. The study will also evaluate the population PK, systemic PK-…
To assess the prevalence of BHD among patients with spontaneous sporadic and familial pneumothorax.
The present study aims at comparing the post-operative lung injury of a lung*protective mechanical ventilation strategy (with the use of higher levels of PEEP and intra*operative recruitment maneuvers) with conventional mechanical ventilation (lower…
* To define the characteristics of children with severe asthma and severe pre school wheeze in terms of clinical features, physiology and biomarker profiles and to compare these with patients with mild-moderate asthma and wheeze* To repeat the…
The major research objective is to prove that the consumption of plant stanol ester enriched yogurts can improve immune function in vivo in asthma patients
Primary objective:- To evaluate the effects of a 10 day-course of prednisolon on coagulation and fibrinolysis parameters in patients with mild-moderate astma, patients with severe asthma, and healthy controls.Secondary objectives:- To compare the…
Primary objective: To demonstrate the superiority of QVA 110/50 µg compared to both QAB149 150 µg and NVA237 50 µg in terms of trough FEV1 (mean of 23 h 15 min and 23 h 45 min post-dose) following 26 weeks of treatment in patients with moderate to…
The aims of the current study are:1. Demonstrate that during noninvasive ventilation a patient with acute respiratory failure is in better synchrony with the ventilator during NAVA compared to PSV mode.2. Demonstrate that the Servo-i ventilator is…